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Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons.

• Pawan Bista, Matthias Pawlowski, +11 authors Thomas Budde
• The Journal of physiology
• 2014

KEY POINTS During the behavioural states of sleep and wakefulness thalamocortical relay neurons fire action potentials in high frequency bursts or tonic sequences, respectively. The modulation of… (More)

The role of two-pore-domain background K+ (K2P) channels in the thalamus

• Pawan Bista, Manuela Cerina, +4 authors Thomas Budde
• Pflügers Archiv - European Journal of Physiology
• 2014

The thalamocortical system is characterized by two fundamentally different activity states, namely synchronized burst firing and tonic action potential generation, which mainly occur during the… (More)

Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.

• Michael Leist, Susanne Rinné, +5 authors Thomas Budde
• The Journal of physiology
• 2017

KEY POINTS The ascending brainstem transmitter acetylcholine depolarizes thalamocortical relay neurons while it induces hyperpolarization in local circuit inhibitory interneurons. Sustained K+… (More)

Two types of interneurons in the mouse lateral geniculate nucleus are characterized by different h-current density.

• Michael Leist, Maia Datunashvilli, +6 authors Thomas Budde
• Scientific reports
• 2016

Although hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels and the corresponding h-current (Ih) have been shown to fundamentally shape the activity pattern in the… (More)

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