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In this paper we describe an adaptive, optimistic synchronisation mechanism for the parallel discrete event simulation of agent-based systems. The mechanism uses the Sphere of Influence (SoI) of an event (the region of the shared simulation state read or written to by the event) to define an adaptive metric which can be used with a throttling mechanism such(More)
Simulating crowds is a challenging but important problem. There are various methodologies in the literature ranging from macroscopic numerical flow simulations to detailed, microscopic agent simulations. One key issue for all crowd simulations is scalability. Some methods address this issue through abstraction, describing global properties of homogeneous(More)
Correct duplication of DNA sequence and its organization into chromatin is central to genome function and stability. However, it remains unclear how cells coordinate DNA synthesis with provision of new histones for chromatin assembly to ensure chromosomal stability. In this paper, we show that replication fork speed is dependent on new histone supply and(More)
Electro-mobility is widely regarded as the future of transportation systems. The shift from fossil fuel-based engines to electro-mobility will pose new challenges to the operations of future transportation systems. Our vision of a smart transportation system for the future entails a collaborative communication and simulation infrastructure that can help to(More)
In eukaryotic cells an uncleavable ubiquitin moiety conjugated to the N-terminus of a protein signals the degradation of the fusion protein via the proteasome-dependent ubiquitin fusion degradation (UFD) pathway. In yeast the molecular mechanism of the UFD pathway has been well characterized. Recently the human E3 ubiquitin-protein ligase TRIP12 was(More)
A large scale High Level Architecture (HLA)-based simulation can be constructed using a network of simulation federations to form a ''federation community''. This effort is often for the sake of enhancing scal-ability, interoperability, composability and enabling information security. Synchronization mechanisms are essential to coordinate the execution of(More)
In this paper we outline an approach to the distributed simulation of agent-based systems using the SIM AGENT toolkit and the High Level Architecture (HLA) simulator interoperability framework. Using a simple Tileworld scenario as an example, we show how the HLA can be used to flexibly distribute a SIM AGENT simulation with different agents being simulated(More)
Maintenance of genome integrity is of critical importance to cells. To identify key regulators of genomic integrity, we screened a human cell line with a kinome small interfering RNA library. WEE1, a major regulator of mitotic entry, and CHK1 were among the genes identified. Both kinases are important negative regulators of CDK1 and -2. Strikingly, WEE1(More)