Michael Lawson

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  • Carlos Cruchaga, Sumitra Chakraverty, Kevin Mayo, Francesco L. M. Vallania, Robi D. Mitra, Kelley Faber +11 others
  • 2012
Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked to familial early onset forms of dementia. Mutation screening in these genes has been performed in either very small series or in single families with late onset AD (LOAD). Similarly, studies in single families have reported mutations in MAPT and GRN associated with clinical(More)
Prediction of the binding strength of untested ligands is a central issue in structure-based drug design. In order to rapidly screen large compound databases, simple scoring schemes are often used in target-based virtual screening. The resulting scores often correlate poorly with biological affinities. More rigorous scoring methods, such as MM-PB/SA,(More)
Chromatin remodeling plays an important role in coordinating gene expression during cortical development, however the identity of molecular complexes present in differentiating cortical neurons that mediate the process remains poorly understood. The A + U-rich element-binding factor 1 (AUF1) is a known regulator of messenger RNA stability and also acts as a(More)
Colorectal cancer accounts for more than 10% of all cancer deaths but is curable, if detected early. We reported previously on a stool-based screening test in which DNA from stool samples is subjected to genome analysis; sensitivity of the test has been limited in part by inefficiency of retrieving DNA from stool. Our aim was to test the impact of a new(More)
We have developed a spatial stochastic model of polarisome formation in mating yeast, focusing on the tight localization of proteins on the membrane. This new model is built on simple mechanistic components, but is able to achieve a highly polarized phenotype with a relatively shallow input gradient. Preliminary results highlight the need for spatial(More)
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