Michael Lang

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Roadrunner is a 1.38 Pflop/s-peak (double precision) hybrid-architecture supercomputer developed by LANL and IBM. It contains 12,240 IBM PowerXCell 8i processors and 12,240 AMD Opteron cores in 3,060 compute nodes. Roadrunner is the first supercomputer to run Linpack at a sustained speed in excess of 1 Pflop/s. In this paper we present a detailed(More)
This work provides a performance analysis of three leading supercomputers that have recently been deployed: Purple, Red Storm and Blue Gene/L. Each of these machines are architecturally diverse, with very different performance characteristics. Each contains over 10,000 processors and has a system peak of over 40 Teraflops. We analyze each system using a(More)
Clustered systems have become a dominant architecture of scalable high-performance super computers. In these large-scale computers, the network performance and scalability is as critical as the computenodes speed. InfiniBandTM has become a commodity networking solution supporting the stringent latency, bandwidth and scalability requirements of these(More)
In order to establish the relative distribution of a GFAP-negative population of astrocytes, and its change in gliotic tissue, sections of the stratum radiatum of the CA1 hippocampal layer of male, adult, Wistar rats were analyzed by immunocytochemical methods. Ten micrometer-thick sections were triple-stained to detect nuclei, glial fibrillary acidic(More)
In this work we present an initial performance evaluation of Intel's latest, secondgeneration quad-core processor, Nehalem, and provide a comparison to first-generation AMD and Intel quad-core processors Barcelona and Tigerton. Nehalem is the first Intel processor to implement a NUMA architecture incorporating QuickPath Interconnect for interconnecting(More)
In the late 1990’s, there was substantial activity within the “Web engineering” research community and a multitude of new Web approaches were proposed. However, numerous studies have revealed major gaps in these approaches, including coverage and interoperability. In order to address these gaps, the Model-Driven Engineering (MDE) paradigm offers a new(More)
Hypermedia systems design presents challenges that are not normally encountered with the development of orthodox ‘traditional’ information systems. In recognition of these challenges, and of the purported inadequacy of conventional software engineering techniques, there is much support in the literature for the view that new, specialized methods are needed.(More)
BACKGROUND Interferon beta has been approved for the treatment of multiple sclerosis (MS). It is believed that immunomodulatory rather than antiviral activity of interferon beta is responsible for disease amelioration. The impact of interferon beta on the chemoattraction of immune cells has not been fully addressed. OBJECTIVE To address the influence of(More)