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  • Michael L. Gargas, R J Burgess, D E Voisard, G H Cason, Melvin E. Andersen
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1989 (First Publication: 1 March 1989)
  • Partition coefficients are required for developing physiologically based pharmacokinetic models used to assess the uptake, distribution, tabolism, and elimination of volatile chemicals in mammals. AExpand
  • Melvin E. Andersen, Harvey J. Clewell, Michael L. Gargas, Franklin Artell Smith, Richard H. Reitz
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1987 (First Publication: 1 February 1987)
  • Methylene chloride (dichloromethane, DCM) is metabolized by two pathways: one dependent on oxidation by mixed function oxidases (MFO) and the other dependent on glutathione S-transferases (GST). AExpand
  • Gregory L. Kedderis, Mark A Carfagna, Stephanie Held, Radhika Batra, James E. J. Murphy, Michael L. Gargas
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1993 (First Publication: 1 December 1993)
  • Furan is both hepatotoxic and hepatocarcinogenic in rats. The kinetics of furan biotransformation by male F-344 rats were studied in vivo and in vitro in order to understand target tissue dosimetry.Expand
  • John W. Nichols, James M. McKim, Melvin E. Andersen, Michael L. Gargas, Harvey J. Clewell, Russell J. Erickson
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1990 (First Publication: 1 December 1990)
  • A physiologically based toxicokinetic model was developed to predict the uptake and disposition of waterborne organic chemicals in fish. The model consists of a set of mass-balance differentialExpand
  • Jeffrey Fisher, Michael L. Gargas, Bruce C. Allen, Melvin E. Andersen
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1991 (First Publication: 1 June 1991)
  • The uptake and metabolism of trichloroethylene (TCE), and the stoichiometric yield and kinetic behavior of one of its major metabolites, trichloroacetic acid (TCA), were compared in Fischer 344 ratsExpand