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A mathematical model is presented to investigate the ordering phenomenon observed in the comparison of alternating to sequential regimens of CMF (cyclophosphamide, methotrexate, 5-fluorouracil) and doxorubicin used in breast cancer chemo-therapy. The ordinary differential equation model incorporates cell cycle specificity and resistance to study why doses(More)
Scope and Purpose – The purpose of this paper is to present a variant of the ellipsoid algorithm that can be used with equalities. This is a significant improvement over the classical algorithm, which yields accurate solutions to convex and many nonconvex nonlinear programming problems but requires the feasible set to be of full dimension and therefore(More)
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