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Broadly neutralizing antibodies targeting a highly conserved region in the hemagglutinin (HA) stem protect against influenza infection. Here, we investigate the protective efficacy of a protein (HB36.6) computationally designed to bind with high affinity to the same region in the HA stem. We show that intranasal delivery of HB36.6 affords protection in mice(More)
Head movement is commonly used in communication to express a positive vs. negative response. However, whereas in US culture vertical head movement is associated with positivity (nodding to say ''yes'') and horizontal head movement is associated with negativity (shaking heads to say ''no''), in Bulgaria the traditional response pattern is reversed, i.e.,(More)
Unlike peripheral lymph nodes (PLN), the mesenteric lymph nodes (MLN) draining the gastrointestinal (GI) tract are exposed to microbes and microbial products from the intestines and as such, are immunologically distinct. GI draining (MLN) have also been shown to be sites of early viral replication and likely impact early events that determine the course of(More)
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