Michael Kirstein

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Cardiac Ca2+ current (ICa) was shown to be regulated by cGMP in a number of different species. Recently, we found that the NO-donor SIN-1 (3-morpholino-sydnonimine) exerts a dual regulation of ICa in frog ventricular myocytes via an accumulation of cGMP. To examine whether NO also regulates Ca2+ channels in human heart, we investigated the effects of SIN-1(More)
Implantable devices for medical use like permanent pacemakers, defibrillators, and fluid pumps depend on an energy provided by batteries. Unfortunately, the battery usually determines the duration of life of these devices, while technical problems occur infrequent. Device replacement for battery exhaustion requires surgical procedures and account for up to(More)
RMI is a well-known middleware that smoothly integrates into Java. RMI uses classical RPC-based client-server interaction, precisely remote method calls. Although RMI has several extension points (i.e., for replacing transport protocols and call semantics), this is not enough for many applications as it can not cope with non-RPC-based communication, fault(More)
In this study we investigated the effect of volume expansion on plasma and atrial concentrations of atrial natriuretic peptide (ANP) in the presence and absence of the parathyroid gland and under normocalcemic and hypocalcemic conditions. After volume expansion ANP concentration in plasma was significantly (p < 0.001) higher in intact (702 +/- 86 pg/ml)(More)
Propafenone is a class I antiarrhythmic drug used to suppress cardiac arrhythmia both of atrial and ventricular origin. We measured fast sodium current (I(Na)+) directly with the loose-patch-clamp technique and confirm the frequency-dependent block of this current. Effects on steady-state current kinetics were small or even in the opposite direction. Since(More)
BACKGROUND Erectile dysfunction (ED) is defined as the inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance. ED may also be an early sign of cardiovascular disease. The main risk factors for coronary heart disease (high LDL, smoking, hypertension, diabetes) and ED are the same. ED after the diagnosis of coronary(More)
Conflicting results have been reported in literature about the influence ofβ-adrenergic stimulation on the fast cardiac sodium current (I Na +). To elucidate these mechanisms in multicellular preparations we used the loose-patch-clamp technique to evaluate the effect of theβ-adrenergic agonist isoproterenol 1–1000 nmol/l. Isoproterenol enhancedI Na+ at all(More)