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Clinical practice guidelines (CPG) are instrumental in standardizing the quality and delivery of care across different practitioners, departments and even institutions. Health practitioners when working with CPG like to reflect on the current best evidence either to validate or to supplement their understanding of the CPG. In this paper we investigate the(More)
In this paper we introduce a framework to supplement and tag computerized CPG with related best-evidence automatically sourced from on-line medical literature repositories. The idea is to provide CPG users with additional published evidence pertaining to the different sections of a CPG of their interest. We present a web-enabled Best-evidence Retrieval and(More)
Immunotherapies are emerging as highly promising approaches for the treatment of cancer. In these approaches, a variety of materials are used to boost immunity against malignant cells. A key component of many of these approaches is functional tumor-specific T cells, but the existence and activity of sufficient T cells in the immune repertoire is not always(More)
Glomerular and other vascular basement membranes were found to contain an antigen that was immunochemically indistinguishable from serum amyloid P-component. There was no immunological cross-reactivity between antisera to serum amyloid P-component and to collagen types I, III, IV, or V. The amyloid P-component antigen was confined to the endothelial aspect,(More)
Adoptive cell therapy (ACT) utilizing gene-modified T cells expressing chimeric antigen receptors (CAR) has emerged as a promising regimen for the treatment of a broad range of cancers including chronic lymphoid leukaemia and neuroblastoma with recent reports of long term remission in some patients. 1,2 However, despite these encouraging outcomes, the(More)
BACKGROUND Combination immunotherapies can be effective against subcutaneous tumors in mice but the effect against orthotopic malignant disease is less well characterized. In particular, a combination of three agonist antibodies, termed Tri-mAb, consisting of anti-DR5, anti-CD40 and anti-CD137 has previously been demonstrated to eradicate a large proportion(More)
The effect of environmental enrichment (EE) on a variety of physiologic and disease processes has been studied in laboratory mice. During EE, a large group of mice are housed in larger cages than the standard cage and are given toys and equipment, enabling more social contact, and providing a greater surface area per mouse, and a more stimulating(More)
The 27 th annual meeting of the Society for Immunotherapy of Cancer (SITC) was held on October 26–28, 2012 in North Bethesda, Maryland and the highlights of the meeting are summarized. The topics covered at this meeting included advances in cancer treatment using adoptive cell therapy (ACT), oncolytic viruses, dendritic cells (DCs), immune check point(More)