Michael Kats

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Cadherins are a family of calcium-dependent cell-surface proteins that are fundamental in controlling the development and maintenance of tissues. Motif B of E-cadherin seems to be a crucial calcium-binding site as single point mutations (D134A and D134K) completely inactivate its adhesion activity. We analyzed peptide models corresponding to motif B (amino(More)
Within the pH range 2-12, the monoclonal chimeric antibody BR96 can be separated into one to five isoforms by micellar electrokinetic capillary chromatography (MECC). The distribution of the immunoglobulin between these isoforms is pH dependent and apparently reversible. Some of the changes in the electrophoretic profile are represented by alterations in(More)
6. 7. I. E. Kovalev, O. Yu. Polevaya, N. P. Danilova, e t al., Khlm.-farm. Zh., 12, 14-19 (1981). I. E. Kovalev, T. No Robakidze, O. Yu. Polevaya, et al., Khim.-farm. Zh., No. i, 39-43 (1982). O, Yu. Polevaya, L. A. Basharova, and I. E. Kovalev, Farmakol. Toksikol., No. 2, 84-89 (1982). E. W. Maynert and F. Washburn, J. Am. Chem. Sot., 75, 700-704 (1953).(More)
One of the most promising approaches to the solution of the problem of the search for new drug substances is the establishment of the structure and physicochemical properties of the corresponding binding sites in the target cells. As a rule, in studies of this kind the authors indicate the physicochemical nature of the interactions of individual fragments(More)
Although multi quantum well (MQW) structure is frequently suggested as the appropriate medium for providing optical gain in nanolasers with low threshold current, we demonstrate that in general bulk gain medium can be a better choice. We show that the high threshold gain required for nanolasers demands high threshold carrier concentrations and therefore a(More)
Compact photonic components are important for the design and fabrication of integrated optical devices and circuits. In the case of light sources, reducing the size can result in improved metrics such as higher packing density and reduced power consumption and also may enhance cavity–emitter interactions such as the Purcell effect. Until recently it was(More)
There is extensive experimental material in the literature on the influence of steroid compounds on the permeability of bimolecular lipid membranes (BLM) relative to ions and molecules of nonelectrolytes. Table 1 presents the results of the action of steroids on phospholipid bilayer membranes -flat and liposomes. These are the most widespread models of(More)
Histamine release from basophilic leukocytes under the effect of autoantigens isolated from involved gingival tissue was examined in periodontitis patients and normal subjects. Anaphylactic autosensitivity was found to be increased in this condition. The results evidence the advisability of antianaphylactic agents administration to patients with(More)
Four major isoforms of the BR96 antibody were separated by micellar electrokinetic capillary chromatography. Heat-induced reversible isoform interconversions were observed at 70 degrees C, and after extended incubation at 80 degrees C, all species irreversibly transformed into a new single peak. In the presence of sodium dodecyl sulfate (1.0 mg/mL), the(More)
  • Michael Kats
  • Nauchnye doklady vysshei shkoly. Biologicheskie…
  • 1985
On the basis of literary data on the relative efficiency of interactions between different ligands and receptors the model of binding site of S2-serotonin receptor has been carried out. The binding site consists of anion centre and two donor acceptor groups, its topography satisfies the stereochemical requirements and phisico-chemical characteristics of(More)