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Ras-GRF Activates Ha-Ras, but Not N-Ras or K-Ras 4B, Proteinin Vivo *
TLDR
These studies represent the first biochemical evidence that a Ras GEF can selectively activate a single Ras homologue in vivo and suggested that residues within the C-terminal hypervariable domains of Ras proteins may dictate, at least in part, the specificity of Ras-GRF/CDC25Mm for Ha-Ras protein.
Mechanism of the Enzymatic Synthesis of 4-(Hydroxymethyl)-2- furancarboxaldehyde-phosphate (4-HFC-P) from Glyceraldehyde-3-phosphate Catalyzed by 4-HFC-P Synthase.
TLDR
The biochemical characterization of the recombinantly expressed MfnB is described to understand its catalytic mechanism and structural analysis and molecular docking are predicted to predict the potential binding sites for two GA-3P molecules in the active site.
Identification of the Final Two Genes Functioning in Methanofuran Biosynthesis in Methanocaldococcus jannaschii
TLDR
The results show that MfnF catalyzes the formation of an ether bond during methanofuran biosynthesis, and further expands the functionality of this enzyme family, while MfnE is a promiscuous enzyme and its possible physiological role is to produce F1-PP.
Donor-Acceptor Pyridinium Salts for Photo-Induced Electron Transfer Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes using Visible Light
TLDR
A method for covalent Trp modification that is suitable for both scenarios by invoking photo-induced electron transfer (PET) as a means of driving efficient reactivity is reported.
Donor-Acceptor Pyridinium Salts for Photo-Induced Electron Transfer Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes using Visible Light
TLDR
A method for covalent Trp modification that is suitable for both scenarios by invoking photo-induced electron transfer (PET) as a means of driving efficient reactivity is reported.