Michael K. Griffin

Learn More
1. We have investigated the inhibitory effects of RP 73401 (piclamilast) and rolipram against human monocyte cyclic AMP-specific phosphodiesterase (PDE4) in relation to their effects on prostaglandin (PG)E2-induced cyclic AMP accumulation and lipopolysaccharide (LPS)-induced TNF alpha production and TNF alpha mRNA expression. 2. PDE4 was found to be the(More)
VOLUME 15, NUMBER 2, 2005 LINCOLN LABORATORY JOURNAL 271 Hyperspectral imaging sensors have been used for more than a decade to aid in the detection and identification of diverse surface targets, topographical details, and geological features. Techniques for scene characterization can utilize individual or combined spectral bands to identify specific(More)
Most biopolymers exist in a plasticized state, whether it is naturally with water or unnaturally with glycerol or other suitable polyol, to make a flexible material. We have found that the extent to which a biopolymer can be plasticized is dependent on its molecular and higher order structures outside of simply molecular weight. Lactalbumin, ovalbumin, corn(More)
In support of hyperspectral sensor system design and parameter tradeoff investigations, an analytical end-to-end remote sensing system performance forecasting model has been extended to the longwave infrared (LWIR). The model uses statistical descriptions of surface emissivities and temperature variations in a scene and propagates them through the effects(More)
Longwave Infrared (LWIR) radiation comprising atmospheric and surface emissions provides information for a number of applications including atmospheric profiling, surface temperature and emissivity estimation, and cloud depiction and characterization. The LWIR spectrum also contains absorption lines for numerous molecular species which can be utilized in(More)
The two-step spin crossover in mononuclear iron(III) complex [Fe(salpm)2 ]ClO4 ⋅0.5 EtOH (1) is shown to be accompanied by a structural phase transition as concluded from (57) Fe Mössbauer spectroscopy and single crystal X-ray diffraction, with spin-state ordering on just one of two sub-lattices in the intermediate magnetic and structural phase. The complex(More)