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Note: This is the first edition of the IHE Radiology: Mammography User's Handbook. New editions will be available at IHE.net and will include examples of more contractual RFP language, more Profiles (for Radiology, IT Infrastructure, Cardiology, and Laboratory domains), and scenarios for workstations and basic PACS installations. The Handbook is intended to(More)
Founded in 1963 by two prominent Austrians living in exile – the sociologist Paul F. Lazarsfeld and the economist Oskar Morgenstern – with the financial support from the Ford Foundation, the Austrian Federal Ministry of Education, and the City of Vienna, the Institute for Advanced Studies (IHS) is the first institution for postgraduate education and(More)
BACKGROUND Low endothelial shear stress (ESS) promotes the development of atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution to inflamed high-risk plaques has not been studied. Our hypothesis was that the lowest values of ESS are responsible for the development of high-risk coronary atherosclerotic plaques(More)
BACKGROUND The natural history of heterogeneous atherosclerotic plaques and the role of local hemodynamic factors throughout their development are unknown. We performed a serial study to assess the role of endothelial shear stress (ESS) and vascular remodeling in the natural history of coronary atherosclerosis. METHODS AND RESULTS Intravascular(More)
Fast thermal maps are a crucial component for many green data center design techniques. However, most state of the art work on thermal mapping ignores critical temporal aspects of thermal behavior and relies on modeling assumptions, such as the steady state assumption, that can reduce their accuracy and cause heat-induced performance throttling when used(More)
Background- The molecular mechanisms that determine the localized formation of thin-capped atheromata in the coronary arteries remain unknown. This study tested the hypothesis that low endothelial shear stress augments the expression of matrix-degrading proteases and thereby promotes the formation of thin-capped atheromata. Methods and Results-(More)
Energy-efficient data center design and management has been a challenge of increasing importance in the past decade due to its potential to save billions of dollars in energy costs. However, the state of the art in design and evaluation of data centers require designers to be expertly familiar with a prohibitively large number of domain-specific design(More)
AIMS To determine laboratory and clinical benefit of oral acetylcysteine, as an adjunct to saline hydration, in chronic renal insufficiency patients undergoing coronary angiography. METHODS AND RESULTS We prospectively studied 80 patients with chronic renal insufficiency (mean [+/-SD] serum creatinine concentration 2.0+/-0.39mg/dl), who underwent coronary(More)
Heparan sulfate proteoglycans (HSPGs) are potent regulators of vascular remodeling and repair. Heparanase is the major enzyme capable of degrading heparan sulfate in mammalian cells. Here we examined the role of heparanase in controlling arterial structure, mechanics, and remodeling. In vitro studies supported that heparanase expression in endothelial cells(More)