Michael Jenik

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The frustratometer is an energy landscape theory-inspired algorithm that aims at quantifying the location of frustration manifested in protein molecules. Frustration is a useful concept for gaining insight to the proteins biological behavior by analyzing how the energy is distributed in protein structures and how mutations or conformational changes shift(More)
Molecularly imprinted polymers for detecting plant pollen were designed as artificial recognition materials for quartz crystal microbalances in the gaseous phase. Imprints of birch (diameter, 25 mum) and nettle (diameter, 15 mum) pollen can be generated by polydimethylsiloxane stamping technique as proven by atomic force microscopy. If pollen grains are(More)
Structuring of thin polymer layers by soft lithography with template bioparticles results in the formation of selective surface cavities, leading to highly effective sensor systems when combined with mass-sensitive transducers, especially QCM. These sensors allow selective differentiation of various stages of development of yeast cells. In order to achieve(More)
Imprinting is a flexible and straightforward technique to generate selective sensor materials e.g. for mass-sensitive detection. Inherently, the strategy suits both molecular analytes and entire micro organisms or cells. Imprinted polyurethanes e.g. are capable of distinguishing the different xylene isomers with very appreciable selectivity factors.(More)
Silanisation of quartz substrate surfaces with a mixture of two chlorosilanes, namely trimethylchlorosilane and 7-octenyldimethylchlorosilane, leads to sensitive coatings for volatile organic compounds (VOC) on surface acoustic wave (SAW) devices. In this way we created monolayers of molecular cavities engulfing the analytes according to host-guest(More)
Molecular imprinting techniques were adapted to design a sensor for the human rhinovirus (HRV) and the foot-and-mouth disease virus (FMDV), which are two representatives of picornaviruses. Stamp imprinting procedures lead to patterned polyurethane layers that depict the geometrical features of the template virus, as confirmed by AFM for HRV. Quartz crystal(More)
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