Michael James

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In both genetic and idiopathic forms of Parkinson's disease (PD), considerable evidence supports the involvement of alpha-synuclein, electron transport chain complex I, protein aggregation, and the ubiquitin-proteasome system. To investigate alterations in the transcription of genes that comprise these pathways, we performed gene expression profiling and(More)
Predictive state representations (PSRs) are powerful models of non-Markovian decision processes that differ from traditional models (e.g., HMMs, POMDPs) by representing state using only observable quantities. Because of this, PSRs can be learned solely using data from interaction with the process. The majority of existing techniques, though, explicitly or(More)
OBJECTIVE The aim of the study was to develop and validate, by consensus, the construct and content of an observations chart for nurses incorporating a modified early warning scoring (MEWS) system for physiological parameters to be used for bedside monitoring on general wards in a public hospital in South Africa. METHODS Delphi and modified face-to-face(More)
Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer's disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for normal tau function and its pathological aggregation. Here, we demonstrate that tau isoforms have different(More)
714 Mayo Clin Proc. Augus T wo of the 32 integrated health networks selected by the Centers for Medicare and Medicaid Services (CMS) to participate in the federal government’s Pioneer Accountable Care Organization (ACO) program are part of Ascension Health. The goal of both participants—Seton Health Alliance in Austin, Texas, and Genesys Physician Hospital(More)
BACKGROUND On South African public hospital wards, observation charts do not incorporate early warning scoring (EWS) systems to inform nurses when to summon assistance. The aim of this trial was to test the impact of a new chart incorporating a modified EWS (MEWS) system and a linked training program on nurses' responses to clinical deterioration (primary(More)
OBJECTIVE For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms. METHODS We first sought to identify genetic associations with(More)
Parallelizing compiler technology has improved in recent years. One area in which compilers have made progress is in handling DOACROSS loops, where crossprocessor data dependencies can inhibit e cient parallelization. In regular DOACROSS loops, where dependencies can be determined at compile time, a useful parallelization technique is pipelining, where each(More)
AIMS Intracardiac electrograms (IEGMs) recorded by implantable cardioverter-defibrillators (ICDs) are essential for arrhythmia diagnosis and ICD therapy assessment. Short IEGM snapshots showing 3-10 s before arrhythmia detection were added to the Biotronik Home Monitoring system in 2005 as the first-generation IEGM Online. The RIONI study tested the primary(More)