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The purpose of this study was to replicate and extend the classic study of vowel acoustics by Peterson and Barney (PB) [J. Acoust. Soc. Am. 24, 175-184 (1952)]. Recordings were made of 45 men, 48 women, and 46 children producing the vowels /i,I,e, epsilon,ae,a, [symbol: see text],O,U,u, lambda,3 iota/ in h-V-d syllables. Formant contours for F1-F4 were(More)
Personalized medicine is expected to benefit from combining genomic information with regular monitoring of physiological states by multiple high-throughput methods. Here, we present an integrative personal omics profile (iPOP), an analysis that combines genomic, transcriptomic, proteomic, metabolomic, and autoantibody profiles from a single individual over(More)
Whole exome sequencing by high-throughput sequencing of target-enriched genomic DNA (exome-seq) has become common in basic and translational research as a means of interrogating the interpretable part of the human genome at relatively low cost. We present a comparison of three major commercial exome sequencing platforms from Agilent, Illumina and Nimblegen(More)
During Drosophila embryogenesis, the Abelson tyrosine kinase (abl) is localized in the axons of the central nervous system (CNS). Mutations in abl have no detectable effect on the morphology of the embryonic CNS, and the mutant animals survive to the pupal and adult stages. In the absence of abl function, however, heterozygous mutations or deletions of(More)
Whole-genome sequencing is becoming commonplace, but the accuracy and completeness of variant calling by the most widely used platforms from Illumina and Complete Genomics have not been reported. Here we sequenced the genome of an individual with both technologies to a high average coverage of ∼76×, and compared their performance with respect to sequence(More)
This study was designed to examine the role of duration in vowel perception by testing listeners on the identification of CVC syllables generated at different durations. Test signals consisted of synthesized versions of 300 utterances selected from a large, multitalker database of /hVd/ syllables [Hillenbrand et al., J. Acoust. Soc. Am. 97, 3099-3111(More)
U87MG is a commonly studied grade IV glioma cell line that has been analyzed in at least 1,700 publications over four decades. In order to comprehensively characterize the genome of this cell line and to serve as a model of broad cancer genome sequencing, we have generated greater than 30x genomic sequence coverage using a novel 50-base mate paired strategy(More)
Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) to produce inflammatory cytokines, such as IL-8. In studies with mouse models, we previously demonstrated that genetic variation in inflammatory responses of endothelial cells to oxidized lipids contributes importantly to atherosclerosis susceptibility. We now(More)
A significant body of evidence has accumulated indicating that vowel identification is influenced by spectral change patterns. For example, a large-scale study of vowel formant patterns showed substantial improvements in category separability when a pattern classifier was trained on multiple samples of the formant pattern rather than a single sample at(More)
OBJECTIVE Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (oxPAPC) accumulates in atherosclerotic lesions and in vitro studies suggest that it mediates chronic inflammatory response in endothelial cells (ECs). The goal of our studies was to identify pathways mediating the induction of inflammatory genes by oxPAPC. METHODS AND RESULTS(More)