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Strain Background Influences Neurotoxicity and Behavioral Abnormalities in Mice Expressing the Tetracycline Transactivator
The tet-off system has been widely used to create transgenic models of neurological disorders including Alzheimer's, Parkinson's, Huntington's, and prion disease. The utility of this system lies inExpand
Specificity and efficiency of reporter expression in adult neural progenitors vary substantially among nestin‐CreERT2 lines
Transgenic lines expressing a controllable form of Cre recombinase have become valuable tools for manipulating gene expression in adult neural progenitors and their progeny. Neural progenitorsExpand
Predetermined Prices and Persistent Effects of Money on Output
This note illustrates a model of predetermined pricing, where firms set a fixed schedule of nominal prices at the time of price readjustment, based on the work of Fischer (1977). This contrasts withExpand
Wild-type microglia do not reverse pathology in mouse models of Rett syndrome
arising from N. C. Derecki et al. 484, 105–109 (2012); doi:10.1038/nature10907Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the X chromosomal gene MECP2 (ref. 1), andExpand
Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex
The entorhinal cortex (EC) plays a central role in episodic memory and is among the earliest sites of neurodegeneration and neurofibrillary tangle formation in Alzheimer’s disease. Given itsExpand
Wild-Type Neural Progenitors Divide and Differentiate Normally in an Amyloid-Rich Environment
Adult neurogenesis is modulated by a balance of extrinsic signals and intrinsic responses that maintain production of new granule cells in the hippocampus. Disorders that disrupt the proliferativeExpand
Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability
We develop a chemogenetic system to temporally control electrical input into the hippocampus that destabilizes spatial coding and disrupts spatial memory acquired prior to neural silencing. Expand
Intersectional Monosynaptic Tracing for Dissecting Subtype-Specific Organization of GABAergic Interneuron Inputs
Functionally and anatomically distinct cortical substructures, such as areas or layers, contain different principal neuron (PN) subtypes that generate output signals representing particularExpand
Regional Cellular Environment Shapes Phenotypic Variations of Hippocampal and Neocortical Chandelier Cells
Different cortical regions processing distinct information, such as the hippocampus and the neocortex, share common cellular components and circuit motifs but form unique networks by modifying theseExpand