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  • David R Lynch, Michael J. Gallagher
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1996 (First Published: 1 October 1996)
  • The dopaminergic antagonist haloperidol also acts at the psychotomimetic sigma receptor and has been proposed to act at N-methyl-D-aspartate (NMDA) receptors. We have investigated the basis of itsContinue Reading
  • J C Brimecombe, Michael J. Gallagher, David R Lynch, Elias Aizenman
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1998 (First Published: 1 August 1998)
  • Haloperidol and ifenprodil are N-methyl-D-aspartate (NMDA) receptor (NR) antagonists with preference for the NR1/NR2B subunit combination. Previous investigations utilizing 125I-MK801 binding assaysContinue Reading
  • Sung Sub Shim, Elfrida R. Grant, Shekhar Singh, Michael J. Gallagher, David R Lynch
  • Medicine, Biology
  • Neurochemistry International
  • 1999 (First Published: 1 March 1999)
  • Haloperidol inhibits NMDA receptors with higher affinity for NMDA receptors composed of NR1/2B compared with NR1/2A. To assess whether the clinical effects of haloperidol and other antipsychoticContinue Reading
  • Elfrida R. Grant, Brian J. Bacskai, +5 authors David R Lynch
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1997 (First Published: 3 January 1997)
  • N-methyl-D-aspartate (NMDA) receptors can mediate cell death in neurons and in non-neuronal cells that express recombinant NMDA receptors. In neurons, increases in intracellular calcium correlateContinue Reading