Michael J. Wise

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Research into late embryogenesis abundant (LEA) proteins has been ongoing for more than 20 years but, although there is a strong association of LEA proteins with abiotic stress tolerance particularly dehydration and cold stress, for most of that time, their function has been entirely obscure. After their initial discovery in plant seeds, three major groups(More)
In spite of years of effort, plagiarism in student assignment submissions still causes considerable difficulties for course designers; if students' work is not their own, how can anyone be certain they have learnt anything? YAP is a system for detecting suspected plagiarism in computer programs and other texts submitted by students. The paper reviews YAP3,(More)
It has argued that systems for detecting similarities in submitted programs must be based on the analysis of program structure. One such system is “Plague”. In this paper, some difficulties with the Plague system are outlined and a new system is described that achieves the same goals as Plague, but in a way that is both more portable and more(More)
The late embryogenesis abundant (LEA) proteins cover a number of loosely related groups of proteins, originally found in plants but now being found in non-plant species. Their precise function is unknown, though considerable evidence suggests that LEA proteins are involved in desiccation resistance. Using a number of statistically-based bioinformatics tools(More)
Sequences from ribosomal RNA (rRNA) genes have made a huge contribution to our current understanding of metazoan phylogeny and indeed the phylogeny of all of life. That said, some parts of this rRNA-based phylogeny remain unresolved. One approach to increase the resolution of these trees would be to use more appropriate models of sequence evolution in(More)
Late embryogenesis abundant (LEA) proteins are produced in maturing seeds and anhydrobiotic plants, animals and microorganisms, in which their expression correlates with desiccation tolerance. However, their function has remained obscure for 20 years. We argue that novel computational tools devised for non-globular proteins might now overcome this problem.(More)
Multiple sequence alignment (MSA) is a crucial first step in the analysis of genomic and proteomic data. Commonly occurring sequence features, such as deletions and insertions, are known to affect the accuracy of MSA programs, but the extent to which alignment accuracy is affected by the positions of insertions and deletions has not been examined(More)
A novel, scalable, quantitative, discrete-event simulator of metabolic and more general reaction pathways-DiMSim-has been developed. Rather than being modeled by systems of differential equations, metabolic pathways are viewed as bipartite graphs consisting of metabolites and reactions, linked by unidirectional or bidirectional arcs, and fluxes of(More)
The protein-disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) is reportedly overexpressed in numerous cancers and plays a role in cancer development. However, to date the molecular functions of AGR2 remain to be characterized. Herein we have identified AGR2 as bound to newly synthesized cargo proteins using a proteomics analysis of(More)