Andrew D. Catling3
Maja Zecevic2
Daniel Gioeli2
3Andrew D. Catling
2Maja Zecevic
2Daniel Gioeli
2Michael L. Brown
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To investigate possible involvement of the mitogen-activated protein (MAP) kinases ERK1 and ERK2 (extracellular signal-regulated kinases) in somatic cell mitosis, we have used indirect immunofluorescence with a highly specific phospho-MAP kinase antibody and found that a portion of the active MAP kinase is localized at kinetochores, asters, and the midbody(More)
  • Diem H.D. Nguyen, Andrew D. Catling, Donna J. Webb, Mauricio Sankovic, Lori A. Walker, Avril V. Somlyo +2 others
  • 1999
Urokinase-type plasminogen activator (uPA) activates the mitogen activated protein (MAP) kinases, extracellular signal-regulated kinase (ERK) 1 and 2, in diverse cell types. In this study, we demonstrate that uPA stimulates migration of MCF-7 breast cancer cells, HT 1080 fibrosarcoma cells, and uPAR-overexpressing MCF-7 cells by a mechanism that depends on(More)
  • Jill K. Slack-Davis, Scott T. Eblen, Maja Zecevic, Scott A. Boerner, Adel Tarcsafalvi, H. Bruce Diaz +4 others
  • 2003
Activation of the Ras-MAPK signal transduction pathway is necessary for biological responses both to growth factors and ECM. Here, we provide evidence that phosphorylation of S298 of MAPK kinase 1 (MEK1) by p21-activated kinase (PAK) is a site of convergence for integrin and growth factor signaling. We find that adhesion to fibronectin induces(More)
  • Mark Axelrod, Vicki L. Gordon, Mark Conaway, Adel Tarcsafalvi, Daniel J. Neitzke, Daniel Gioeli +1 other
  • 2013
Constitutively activated signaling molecules are often the primary drivers of malignancy, and are favored targets for therapeutic intervention. However, the effectiveness of targeted inhibition of cell signaling can be blunted by compensatory signaling which generates adaptive resistance mechanisms and reduces therapeutic responses. Therefore, it is(More)
  • Brian J. Capaldo, Devin Roller, Mark J. Axelrod, Alex F. Koeppel, Emanuel F. Petricoin, Craig L. Slingluff +5 others
  • 2015
Fifty percent of cutaneous melanomas are driven by activated BRAFV600E, but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and develop drug combinations that target these resistance mechanisms.(More)
Hypoxia in shallow lakes represents a stochastic disturbance that may elicit a resource pulse through fish decomposition, altering nutrient availability and temporal variability of ecosystem productivity. We measured nutrient availability, primary and secondary production, and temporal variability from April through September in no, moderate, and high(More)
Fishes play a functional role in structuring aquatic ecosystems through top-down and bottom-up processes. Adult common carp (Cyprinus carpio) are well recognized for their middle-out effects on aquatic ecosystems that can shift shallow lakes from the clear- to turbid-water stable state through benthic foraging activities. However, less is known about(More)
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