Michael J. Toth

Learn More
member individuals (online only): $370.00, APS members: online is free. Subscriptions from outside the United States are payable in US currency or full equivalent. Subscriptions are accepted on a calendar-year basis only. 17601. The code at the bottom of the first page of an article indicates the copyright owner's consent that copies of that article may be(More)
Skeletal muscle contractile function declines with aging, disease, and disuse. In vivo muscle contractile function depends on a variety of factors, but force, contractile velocity and power generating capacity ultimately derive from the summed contribution of single muscle fibers. The contractile performance of these fibers are, in turn, dependent upon the(More)
Chronic heart failure is characterized by changes in skeletal muscle that contribute to physical disability. Most studies to date have investigated defects in skeletal muscle oxidative capacity. In contrast, less is known about how heart failure affects myofibrillar protein metabolism. Thus we examined the effect of heart failure on skeletal muscle(More)
Age-related changes in myosin heavy chain (MHC) phenotype impact both the quantity and functional character of skeletal muscle. The present study was undertaken to examine the hypothesis that age-related changes in MHC mRNA abundance underlie alterations in protein synthesis rates and content. We measured the abundance of mRNA for MHC isoforms (MHC I, MHC(More)
We examined the effect of knee osteoarthritis on the rate of torque development (RTD) of the knee extensors in older adults with advanced-stage knee osteoarthritis (OA; n=15) and recreationally-active controls (n=15) of similar age, sex and health status, as well as the relationship between RTD and the size and contractility of single muscle fibers. OA(More)
Cancer cachexia contributes to poor prognosis through progressive depletion of the body's energy and protein reserves; research is revealing the impact of the quantitly of these reserves on survival. Our group has exploitated computed tomography (CT) images to study body composition in cancer patients. We argue that CT taken for the purposes of diagnosis(More)
OBJECTIVE To evaluate the role of physiologic levels of androgens and their precursors in the regulation of body composition, energy and substrate metabolism and aerobic capacity in healthy, cycling, premenopausal women. EXPERIMENTAL We evaluated 30 young (27±1 year) premenopausal, non-obese (23±0.5 kg/m(2)), normally-cycling women, without clinical or(More)
  • 1