Learn More
Resting metabolic rate (RMR) data have been normalized by dividing RMR by fat-free mass (FFM) (ie, ratio method), or by using a regression-based approach. We compared both data-normalization procedures on age- and sex-related differences in RMR. The ratio method showed no differences in adjusted RMR between older men (0.084 +/- 0.004 kJ.FFM-1.min-1) and(More)
Menopause-related changes in body fat distribution may partially explain the greater risk of cardiovascular and metabolic disease during the postmenopausal years. To date, however, the effect of the menopause transition on body fat distribution remains unclear. Cross-sectional and longitudinal studies using waist circumference or the waist-to-hip ratio show(More)
Age-related loss of skeletal muscle mass and function is implicated in the development of disease and physical disability. However, little is known about how age affects skeletal muscle structure at the cellular and ultrastructural levels or how such alterations impact function. Thus we examined skeletal muscle structure at the tissue, cellular, and(More)
Skeletal muscle contractile function declines with age and age-associated diseases. Although muscle atrophy undoubtedly contributes to this decrease, recent findings suggest that reduced myofilament protein content and function also may participate. Based on these data, we propose that age- and disease-related alterations in myofilament proteins represent(More)
BACKGROUND The goal of this study was to determine if heart failure alters knee extensor muscle torque, power production or contractile velocity. METHODS Heart failure patients (n=11; 70.4±4.3 yrs) and controls (n=11; 70.3±3.4 yrs) matched for age and sex were evaluated for knee extensor contractile performance under isometric and isokinetic conditions(More)
Skeletal muscle function is impaired in heart failure patients due, in part, to loss of myofibrillar protein content, in particular myosin. In the present study, we utilized small-amplitude sinusoidal analysis for the first time in single human skeletal muscle fibres to measure muscle mechanics, including cross-bridge kinetics, to determine if heart failure(More)
Adiposity increases with age. The size of the adipose tissue mass is determined by the balance between the recruitment of lipid substrates (ie free fatty acids) from adipose tissue and their subsequent oxidation by respiring tissues. Thus, change in the liberation of free fatty acids from adipocytes, the capacity of respiring tissue to oxidize free fatty(More)
BACKGROUND Patients with chronic heart failure (HF) frequently experience skeletal muscle weakness that limits physical function. The mechanisms underlying muscle weakness, however, have not been clearly defined. METHODS AND RESULTS This study examined the hypothesis that HF promotes a loss of myosin protein from single skeletal muscle fibers, which in(More)
OBJECTIVE The metabolic equivalent (MET) is a commonly used method of quantifying the energy cost and intensity of physical activity. Recent studies have questioned the accuracy of the well-accepted value of a MET of 3.5 mL O2.kg(-1).min(-1). The goal of the present study was to compare the traditionally accepted value for 1 MET to direct measures of(More)
OBJECTIVE Low sex hormone-binding globulin (SHBG) levels in women are associated not only with hyperinsulinemia, increased risk for cardiovascular disease, and type 2 diabetes but also with excess body fatness and abdominal obesity. We tested the hypothesis that an elevated total or intra-abdominal adipose tissue accumulation mediates the relationship(More)