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BACKGROUND The goal of this study was to investigate psychosocial disability in relation to depressive symptom severity during the long-term course of unipolar major depressive disorder (MDD). METHODS Monthly ratings of impairment in major life functions and social relationships were obtained during an average of 10 years' systematic follow-up of 371(More)
OBJECTIVE This study investigated the influence of incomplete recovery from first lifetime major depressive episodes on long-term outcome. METHOD After their first lifetime major depressive episode, patients were divided into asymptomatic (N=70) and residual subthreshold depressive symptom (N=26) recovery groups and compared on longitudinal course during(More)
BACKGROUND Major depressive syndromes have been found to be prevalent, disabling, and often persistent during the stress of bereavement. To add to the burden of mood changes associated with bereavement, a substantial number of bereaved individuals may suffer from depressive symptoms that do not quite equal the requisite number to meet criteria for a major(More)
Two versions of a new high-resolution x-ray computed tomography system are being developed to screen mutagenized mice in the Oak Ridge National Laboratory Mammalian Genetics Research Facility. The first prototype employs a single-pixel cadmium zinc telluride detector with a pinhole collimator operating in pulse counting mode. The second version employs a(More)
The islet amyloid polypeptide (IAPP) or amylin is a pancreatic hormone and crucially involved in the pathogenesis of type-II diabetes mellitus (T2DM). Aggregation and amyloid formation of IAPP is considered as the primary culprit for pancreatic beta-cell loss in T2DM patients. In this study, first X-ray reflectivity (XRR) measurements on IAPP at lipid(More)
The Feldkamp algorithm is widely accepted as a practical conebeam reconstruction method for three-dimensional x-ray computed tomography. We introduce focus of attention, an effective and simple to implement datadriven preprocessing scheme, for identifying a convex subset of voxels that include all those relevant to the object under study. By concentrating(More)
Supramolecular chemistry holds unique prospects for the fabrication of novel functional materials. Molecular precisely defined subunits (which may already be rather complex self-assemblies) form even more complex structures that exhibit functionalities not provided by the individual building blocks. The coupling of the covalently bonded subunits by(More)