Michael J Murphy

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Pediatric melanoma is rare but increasing in incidence. Because early diagnosis and treatment improves prognosis, clinicians need to include it as a possible diagnosis when evaluating a pigmented lesion in a pediatric patient. Some risk factors for melanoma include xeroderma pigmentosum, giant congenital melanocytic nevi, dysplastic nevus syndrome, atypical(More)
Loss of CD7 expression by neoplastic lymphocytes is considered a distinguishing characteristic of mycosis fungoides (MF) and cutaneous T-cell lymphoma. Reports to date examining for the CD7 immunophenotype in MF have been performed on fresh-frozen tissue. In this study, we used a paraffin-reactive antibody directed against CD7 to determine its range of(More)
Psoriasis is the prototype of a group of cutaneous disorders (psoriasiform dermatitides) that show psoriasiform epidermal hyperplasia, defined as regular elongation of the rete ridges with preservation of the rete ridge-dermal papillae pattern. Depending on whether the lesion is early or resolving, psoriasiform epidermal changes may be subtle or prominent.(More)
BACKGROUND Acquired lymphedema of the genitalia is a rare childhood presentation and is more common in elderly individuals secondary to pelvic/abdomenal malignancy or its therapy or worldwide due to filariasis. OBJECTIVE Herein, we report a case of a healthy 11-year-old boy who presented with a 1-year history of chronic, asymptomatic scrotal and penile(More)
UNLABELLED Accurate evaluation of patients with suspected or known cutaneous lymphoma requires the integration of many sources and types of information, including clinical evaluation, microscopic analysis of tissue, immunophenotyping, gene rearrangement studies, clinical staging, and longitudinal observation. Diagnoses should be based on knowledge of(More)
BACKGROUND S-phase kinase associated protein-2 (Skp2) ubiquitin ligase p45(SKP2) is important in the degradation of p27kip1 (a cyclin dependent kinase inhibitor) and progression through the G1-S cell-cycle checkpoint. Low levels of p27 and high levels of Skp2 are related to poor prognosis in some cancers. METHODS Clinicopathologic features and(More)
To the Editor, Classic poromas (CPs) are relatively common benign adnexal neoplasms that are typically located on the palms and soles, although other cutaneous sites can be affected. CPs are usually nonpigmented, but lesional pigmentation can occasionally be seen. A 66-year-old man presented with a crusted pigmented nodule on his left forearm. The clinical(More)
To the Editor: The coexistence of molluscum contagiosum virus (MCV) infection in an epidermal inclusion cyst is rarely described. We report 2 additional cases of MCV infection in benign cutaneous epithelial cystic lesions with different histopathologic features. The possible different pathogenesis of these cystic skin lesions with regard to MCV infection is(More)
BACKGROUND Commonly described histologic 'clues' to the diagnosis of dermatophytosis include neutrophils in the stratum corneum and/or epidermis, compact orthokeratosis and identification of fungal hyphae between two zones of cornified cells. Prominent (striking) papillary dermal edema (PPDE) is not commonly reported with dermatophytosis (tinea corporis).(More)