Michael J. Morrissey

Learn More
The 2009 pandemic H1N1 influenza pandemic demonstrated the global health threat of reassortant influenza strains. Herein, we report a detailed analysis of plasmablast and monoclonal antibody responses induced by pandemic H1N1 infection in humans. Unlike antibodies elicited by annual influenza vaccinations, most neutralizing antibodies induced by pandemic(More)
The aim of this study is to identify a possible function of Active Sleep (AS), also known as Rapid Eye Movement Sleep (REM) in humans, as a protective state during early Central Nervous System (CNS) development. Previous research suggest pharmacological agents that inhibit high levels of neuronal activity in the CNS (e.g., benzodiazepines, ethanol, and(More)
Analysis and classification of sleep stages is a fundamental part of basic sleep research. Rat sleep stages are scored based on electrocorticographic (ECoG) signals recorded from electrodes implanted epidurally and electromyographic (EMG) signals from the temporalis or nuchal muscle. An automated sleep scoring system was developed using a support vector(More)
Breakdown of B cell tolerance is a cardinal feature of systemic lupus erythematosus (SLE). Increased numbers of autoreactive mature naïve B cells have been described in SLE patients and autoantibodies have been shown to arise from autoreactive and non-autoreactive precursors. How these defects, in the regulation of B cell tolerance and selection, influence(More)
The mTORC1 inhibitor everolimus (Afinitor/RAD001) has been approved for multiple cancer indications, including ER(+)/HER2(-) metastatic breast cancer. However, the combination of everolimus with the dual PI3K/mTOR inhibitor BEZ235 was shown to be more efficacious than either everolimus or BEZ235 alone in preclinical models. Herein, we describe a male breast(More)
Celiac disease (CD) is an immune mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) 1 are generated in response to the exogenous antigen gluten 2 in individuals who are HLA-DQ2 or HLA-DQ8 3. We assessed in a comprehensive and non-biased manner the IgA anti-TG2 response by expression cloning of the antibody repertoire on(More)
Influenza is the seventh leading cause of death in the United States (Beigel, 2008), with the elderly , the very young, pregnant women, and otherwise immune-compromised populations accounting for >90% of influenza-related deaths. The pandemic H1N1 influenza virus strain is immunologically distinct from other influenza The 2009 pandemic HN influenza pandemic(More)
A body of literature is developing which identifies an additional stage of sleep in rats, cats and mice. Intermediate stage (IS) sleep is a measurable sleep stage that is maintained by the hyperpolarization of GABA(A) containing thalamocortical neurons. The present study attempts to clarify inconsistencies within the sleep spindle literature. Most notably,(More)
  • 1