Michael J. McArdle

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Impaired brain energy production, reflected by reduced cortical glucose metabolism seen on 2-FDG PET scans, has emerged as a robust biomarker of mild cognitive impairment (MCI). Progression from MCI to Alzheimer's disease (AD) shows further decline of cortical 2-FDG uptake, implying worsening bioenergetics. We characterized respiration, respiratory protein(More)
Recent studies demonstrating feminization of effluent-exposed wild-caught male fish in the UK have prompted much research regarding the estrogenic activity of effluent from municipal sewage treatment plants (MSTPs). To investigate the estrogenicity and cytochrome P450 1A (CYP1A) induction potency of MSTP effluent, two species of fish, adult male mummichogs,(More)
R enal artery denervation (RDN) is a catheter-based technique designed to decrease renal sympathetic nervous system (SNS) signaling and return the body to more physiological homeostasis. Preliminary investigations suggested an excellent therapeutic profile in resistant hyperten-sion, 1,2 but results from SYMPLICITY HTN-3, a randomized control trial (RCT) of(More)
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