Michael J. McArdle

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Impaired brain energy production, reflected by reduced cortical glucose metabolism seen on 2-FDG PET scans, has emerged as a robust biomarker of mild cognitive impairment (MCI). Progression from MCI to Alzheimer's disease (AD) shows further decline of cortical 2-FDG uptake, implying worsening bioenergetics. We characterized respiration, respiratory protein(More)
R enal artery denervation (RDN) is a catheter-based technique designed to decrease renal sympathetic nervous system (SNS) signaling and return the body to more physiological homeostasis. Preliminary investigations suggested an excellent therapeutic profile in resistant hyperten-sion, 1,2 but results from SYMPLICITY HTN-3, a randomized control trial (RCT) of(More)
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