Michael J Karadimos

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Specification and maturation of insulin(+) cells accompanies a transition in expression of Maf family of transcription factors. In development, MafA is expressed after specification of insulin(+) cells that are expressing another Maf factor, MafB; after birth, these insulin(+) MafA(+) cells stop MafB expression and gain glucose responsiveness. Current(More)
Over the last decade, our knowledge of β-cell biology has expanded with the use of new scientific techniques and strategies. Growth factors, hormones and small molecules have been shown to enhance β-cell proliferation and function. Stem cell technology and research into the developmental biology of the pancreas have yielded new methods for in vivo and in(More)
213 ISSN 1758-1907 10.2217/DMT.12.21 © 2012 Future Medicine Ltd Diabetes Manage. (2012) 2(3), 213–222 Summary Over the last decade, our knowledge of b-cell biology has expanded with the use of new scientific techniques and strategies. Growth factors, hormones and small molecules have been shown to enhance b-cell proliferation and function. Stem cell(More)
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