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The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake, miso and soy sauce. Our analysis of(More)
The opportunistic human pathogenic fungus Penicillium marneffei is dimorphic and is thereby capable of growth either as filamentous multinucleate hyphae or as uninucleate yeast cells which divide by fission. The dimorphic switch is temperature dependent and requires regulated changes in morphology and cell shape. Cdc42p is a Rho family GTPase which in(More)
Siderophores play a central role in iron metabolism and virulence of most fungi. Both Aspergillus fumigatus and Aspergillus nidulans excrete the siderophore triacetylfusarinine C (TAFC) for iron acquisition. In A. fumigatus, green fluorescence protein-tagging revealed peroxisomal localization of the TAFC biosynthetic enzymes SidI (mevalonyl-CoA ligase),(More)
The filamentous fungus Neurospora crassa, which has played an important role in the development of modern genetics, has several unique genome-defense mechanisms, including a process called repeat-induced point mutation. The draft genome sequence has revealed several unusual features, which suggest that the evolution of N. crassa has been greatly influenced(More)
The CCAAT sequence in the amdS promoter of Aspergillus nidulans is recognized by AnCF, a complex consisting of the three evolutionary conserved subunits HapB, HapC, and HapE. In this study we have investigated the effect of AnCF on the chromatin structure of the amdS gene. The AnCF complex and the CCAAT sequence were found to be necessary for the formation(More)
The opportunistic human pathogen Penicillium marneffei exhibits a temperature-dependent dimorphic switch. At 25Њ, multinucleate, septate hyphae that can undergo differentiation to produce asexual spores (conidia) are produced. At 37Њ hyphae undergo arthroconidiation to produce uninucleate yeast cells that divide by fission. This work describes the cloning(More)
The focus of this project is to create research in teacher education that positively impacts teacher recruitment, preparation and retention in urban environments. The novel approach we are using to attack this problem is that of capturing, analyzing, synthesizing and simulating human interactions in Mixed Reality (part real, part synthetic) environments,(More)
The assimilation of nitrate, a most important soil nitrogen source, is tightly regulated in microorganisms and plants. In Aspergillus nidulans, during the transcriptional activation process of nitrate assimilatory genes, the interaction between the pathway-specific transcription factor NirA and the exportin KapK/CRM1 is disrupted, and this leads to rapid(More)