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- N A Baker, D Sept, S Joseph, M J Holst, J A McCammon
- Proceedings of the National Academy of Sciences…
- 2001

Evaluation of the electrostatic properties of biomolecules has become a standard practice in molecular biophysics. Foremost among the models used to elucidate the electrostatic potential is the Poisson-Boltzmann equation; however, existing methods for solving this equation have limited the scope of accurate electrostatic calculations to relatively small… (More)

- Michael J. Holst, Faisal Saied
- Journal of Computational Chemistry
- 1993

A multigrid method is presented for the numerical solution of the linearized Poisson-Boltzmann equation arising in molecular biophysics. The equation is discretized with the finite volume method, and the numerical solution of the discrete equations is accomplished with multiple grid techniques originally developed for two-dimensional interface problems… (More)

- Long Chen, Michael J. Holst, Jinchao Xu
- Math. Comput.
- 2009

The convergence and optimality of adaptive mixed finite element methods for the Poisson equation are established in this paper. The main difficulty for mixed finite element methods is the lack of minimization principle and thus the failure of orthogonal-ity. A quasi-orthogonality property is proved using the fact that the error is orthogonal to the… (More)

- Michael J. Holst
- Adv. Comput. Math.
- 2001

Adaptive multilevel finite element methods are developed and analyzed for certain elliptic systems arising in geometric analysis and general relativity. This class of nonlinear elliptic systems of tensor equations on manifolds is first reviewed, and then adaptive multilevel finite element methods for approximating solutions to this class of problems are… (More)

- Randolph E. Bank, Michael J. Holst
- SIAM Review
- 2000

We present a new approach to the use of parallel computers with adaptive finite element methods. This approach addresses the load balancing problem in a new way, requiring far less communication than current approaches. It also allows existing sequential adaptive PDE codes such as PLTMG and MC to run in a parallel environment without a large investment in… (More)

- M. J. Holst
- 1994

- SPIS TREŚCI, Bernardo Cockburn, +44 authors Michael Eisermann
- 2010

1 Superconvergent discontinuous Galerkin methods for second-order elliptic problems / A multiscale finite element method for partial differential equations posed in domains with rough boundaries / Alexandre L. Madureira 35 Convergence and optimality of adaptive mixed finite element methods / 79 Overlapping additive Schwarz preconditioners for elliptic PDEs… (More)

- Long Chen, Michael J. Holst, Jinchao Xu
- SIAM J. Numerical Analysis
- 2007

A widely used electrostatics model in the biomolecular modeling community , the nonlinear Poisson–Boltzmann equation, along with its finite element approximation , are analyzed in this paper. A regularized Poisson–Boltzmann equation is introduced as an auxiliary problem, making it possible to study the original nonlinear equation with delta distribution… (More)

- Michael J. Holst, Ari Stern
- Foundations of Computational Mathematics
- 2012

showed that a large class of mixed finite element methods can be formulated naturally on Hilbert complexes, where using a Galerkin-like approach, one solves a variational problem on a finite-dimensional subcomplex. In a seemingly unrelated research direction, Dziuk [Lecture Notes in Math., vol. 1357 (1988), 142–155] analyzed a class of nodal finite elements… (More)