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The Palmer Drought Severity Index (PDSI) has been used for more than 30 years to quantify the long-term drought conditions for a given location and time. However, a common critique of the PDSI is that the behavior of the index at various locations is inconsistent, making spatial comparisons of PDSI values difficult, if not meaningless. A self-calibrating(More)
PURPOSE To evaluate the basic pharmacokinetic (PK) characteristics of imatinib mesylate and assess the relationship between the PK and pharmacodynamic (PD) properties of the drug. PATIENTS AND METHODS The PK and PD properties of imatinib were investigated during a phase I trial that included 64 adult patients with Philadelphia chromosome-positive(More)
PURPOSE Phase I: To determine the maximum tolerated doses, toxicities, and pharmacokinetics of imatinib mesylate (Gleevec) in patients with malignant gliomas taking enzyme-inducing antiepileptic drugs (EIAED) or not taking EIAED. Phase II: To determine the therapeutic efficacy of imatinib. EXPERIMENTAL DESIGN Phase I component used an interpatient dose(More)
Imatinib mesylate (GLEEVEC, GLIVEC, formerly STI571) has demonstrated unprecedented efficacy as first-line therapy for treatment for all phases of chronic myelogenous leukemia and metastatic and unresectable malignant gastrointestinal stromal tumors. Disposition and biotransformation of imatinib were studied in four male healthy volunteers after a single(More)
The purpose of this study was to investigate the absolute bioavailability of a single oral dose of imatinib (Glivec), 400 mg (capsules vs. oral solution), compared with imatinib, 100 mg (intravenous [i.v.] infusion), in healthy subjects. Twelve subjects received a single treatment in each treatment period: a 400-mg oral dose of imatinib in capsule form or(More)
The study under discussion was a drug-drug interaction study in which the effect of ketoconazole, a potent CYP450 3A4 inhibitor, on the pharmacokinetics of Glivec (imatinib) was investigated. A total of 14 healthy subjects (13 male, 1 female) were enrolled in this study. Each subject received a single oral dose of imatinib 200 mg alone, and a single oral(More)
BACKGROUND This study evaluates the correlation between imatinib trough plasma concentrations (C(min)) and clinical response and safety in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase in the Tyrosine Kinase Inhibitor OPtimization and Selectivity (TOPS) trial. DESIGN AND METHODS Patients were(More)
What: Fifty-four participants from 22 countries, including drought experts from each of the six WMO regions, met to discuss the development of standards for drought indices and guidelines for drought early warning systems I mproved drought monitoring and early warning systems are urgently needed to cope with current and potentially changing drought patterns(More)
The Standardized Precipitation Evapotranspiration Index (SPEI) was computed based on the monthly precipitation and air temperature values at 609 locations over China during the period 1951–2010.Various characteristics of drought across China were examined including: long-term trends, percentage of area affected, intensity, duration, and drought frequency.(More)
Purpose and Use of this Guide This guide was developed as part of an action item addressed by the Preparedness and Mitigation Working Group of the Western Drought Coordination Council, prepared with input and review by members of the working group. It is designed to be a step-by-step process for users to identify actions that can be taken to reduce(More)