Michael J Handley

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We present a novel ice/firn core melter system that uses fraction collectors to collect discrete, high-resolution (<1 cm/sample possible), continuous, coregistered meltwater samples for analysis of eight major ions by ion chromatography (IC), >32 trace elements by inductively coupled plasma sectorfield mass spectrometry (ICP-SMS), and stable oxygen and(More)
Given the increasing interest in using peat bogs as archives of atmospheric metal deposition, the lack of validated sample preparation methods and suitable certified reference materials has hindered not only the quality assurance of the generated analytical data but also the interpretation and comparison of peat core metal profiles from different(More)
[1] A high-resolution, 8000 year-long ice core record from the Mt. Logan summit plateau (5300 m asl) reveals the initiation of trans-Pacific lead (Pb) pollution by ca. 1730, and a >10-fold increase in Pb concentration (1981 – 1998 mean = 68.9 ng/l) above natural background (5.6 ng/l) attributed to rising anthropogenic Pb emissions from Asia. The largest(More)
[1] A highly resolved Mt. Everest ice core reveals a decrease in marine and increase in continental air masses related to relatively high summer surface pressure over Mongolia, and reduction in northward incursions of the summer South Asian monsoon since $1400 AD. Previously published proxy records from lower sites south of the Himalayas indicate(More)
[1] Trends and sources of lead (Pb) aerosol pollution in the North Pacific rim of North America from 1850 to 2001 are investigated using a high-resolution (subannual to annual) ice core record recovered from Eclipse Icefield (3017 masl; St. Elias Mountains, Canada). Beginning in the early 1940s, increasing Pb concentration at Eclipse Icefield occurs(More)
We present the first high-resolution (sub-annual) dust particle data set from West Antarctica, developed from the West Antarctic Ice Sheet (WAIS) Divide deep ice core (79.468 • S, 112.086 • W), and use it to reconstruct changes in atmospheric circulation over the past 2400 years. We find a background dust flux of ∼ 4 mg m −2 year −1 and a mode particle size(More)
To assess the role of methodological differences on measured trace-element concentrations in ice cores, we developed an experiment to test the effects of acidification strength and time on dust dissolution using snow samples collected in West Antarctica and Alaska. We leached Antarctic samples for 3 months at room temperature using nitric acid at(More)
BACKGROUND Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi's Sarcoma (KS) treatment, the role that ABCB1 plays in mediating multidrug resistance (MDR) in a fully transformed KS cell line (SLK) was explored. (More)
Novel alphavbeta3 antagonists based on the N-aryl-gamma-lactam scaffold were prepared. SAR studies led to the identification of potent antagonists for alphavbeta3 receptor with excellent selectivity against the structurally related alpha(IIb)beta3 receptor. Additional interactions of N-aryl-gamma-lactam derivatives with alphavbeta3 were found when compared(More)