Michael J Gebhardt

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Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in(More)
<italic>CoDecide is an experimental user interface toolkit that offers an extension to spreadsheet concepts specifically geared towards support for cooperative analysis of the kinds of multi-dimensional data encountered in data warehousing. It is distinguished from previous proposals by direct support for drill-down/roll-up analysis without redesign of an(More)
Serotonin syndrome (SS) is a serious life-threatening disorder associated with elevated brain serotonergic function. With the growing use of serotonergic drugs, SS affects a large portion of general population, becoming a major biomedical concern. SS-like behaviors have also been reported in animals following administration of serotonergic drugs. Although(More)
UNLABELLED The increasing emergence of antibiotic-resistant bacterial pathogens represents a serious risk to human health and the entire health care system. Many currently circulating strains of Acinetobacter baumannii exhibit resistance to multiple antibiotics. A key limitation in combating A. baumannii is that our understanding of the molecular mechanisms(More)
Negotiation in cooperative modeling environments requires stakeholders to achieve a shared understanding while maintaining their own interpretation, in order to achieve creative design solutions. Complementing meeting-oriented groupware systems which continuously enforce a central group perspective, we present an qpreach thar maintains multiple perspectives(More)
This study characterises the response properties of the sensilla located on the prothoracic disc organ of the beetle Acanthocnemus nigricans, such as intensity response functions and temporal coding properties. Warming the sensilla by a red laser accelerated their ongoing spiking activity, cessation of the stimulus suppressed their firing as revealed by(More)
In crickets (Gryllus campestris, Gryllus bimaculatus) the contribution of the suboesophageal ganglia (SOG) and thoracic ganglia to the generation of antennal movements during visual tracking, walking and flight was investigated by the transection of connectives. Transection of one circumoesophageal connective abolished the movements and postures of the(More)
A metabolite of the kynurenine pathway, kynurenic acid (KYNA) is an important endogenous neuromodulator and neuroprotector, that also exerts neurotropic effects following exogenous administration. In humans and animals, KYNA regulates affective and cognitive responses, acting mainly as an antagonist of glutamatergic receptors. However, the complete(More)
Brain monoamines play a key role in the regulation of behavior. Reserpine depletes monoamines, and causes depression and hypoactivity in humans and rodents. In contrast, d-amphetamine increases brain monoamines' levels, and evokes hyperactivity and anxiety. However, the effects of these agents on behavior and in relation to monoamine levels remain poorly(More)