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This study aimed to analyse whether the precision of a three-dimensional mobile image intensifier (ISO-C 3D) differs from conventional two-dimensional fluoroscopy and high resolution CT scan in a fracture model of the proximal tibia. A depression fracture of the medial plateau (AO/OTA 41-B2.3) was created in 12 formalin-fixed, human cadaver knees. The(More)
BACKGROUND The efficiency of cochlear implants (CIs) is affected by postoperative connective tissue growth around the electrode array. This tissue formation is thought to be the cause behind post-operative increases in impedance. Dexamethasone (DEX) eluting CIs may reduce fibrous tissue growth around the electrode array subsequently moderating elevations in(More)
AIMS Life-threatening arrhythmias are a major problem in chronic heart failure (CHF). The aim of the present study was to investigate the mechanism underlying the low proarrhythmic potential of amiodarone in a model of pacing-induced heart failure. METHODS AND RESULTS Heart failure was induced in 35 female rabbits by rapid ventricular pacing, resulting in(More)
Hypericin is a naturally occurring photosensitizer that displays potent antiviral activity in the presence of light. The absence of light in many regions of the body may preclude the use of hypericin and other photosensitizers as therapeutic compounds for the treatment of viral infections in vivo. The chemiluminescent oxidation of luciferin by the(More)
Hypocrellin A displays photoinduced antiviral activity, in particular against the human immunodeficiency virus (HIV), as does its counterpart, hypericin. Although hypocrellin A, like hypericin, executes an excited-state intramolecular proton transfer, it differs from hypericin in two important ways. Unlike hypericin, hypocrellin A absolutely requires oxygen(More)
INTRODUCTION Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with resuscitation. MATERIALS AND METHODS(More)
During a 3.3-year period, gastric dilatation-volvulus was diagnosed in 134 dogs. Thirteen of them died or were euthanatized prior to treatment. In 33 dogs, decompression and emptying of the stomach was successfully performed via a gastric tube. Rate of recurrence was 75.8% (25/33) for these dogs. Eighty-eight dogs were treated surgically. In all but 1(More)
The authors assume no responsibility and make no guarantee for the use of drugs listed in this book. The authors / publisher shall not be held responsible for any damages that might be incurred by the recommended use of drugs or dosages contained within this textbook. In many cases controlled research concerning the use of a given drug in animals is(More)
Osteogenesis imperfecta (OI) is a hereditary disease occurring in humans and dogs. It is characterized by extremely fragile bones and teeth. Most human and some canine OI cases are caused by mutations in the COL1A1 and COL1A2 genes encoding the subunits of collagen I. Recently, mutations in the CRTAP and LEPRE1 genes were found to cause some rare forms of(More)
A five-year-old, castrated, male chinchilla rabbit was presented for evaluation of recurrent bilateral exophthalmos. Besides a transient and stress-related exophthalmos with protrusion of both third eyelids, the ophthalmological examination was unremarkable. Plain radiography of the thorax revealed a large precardial mass of soft tissue density. Cytological(More)