Michael J. Coffey

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Previous studies have demonstrated that cyclopentenone prostaglandins (cyPG) inhibit HIV-1 replication in various cell types. We investigated the role of PG in the replication of HIV-1 in primary macrophages. The cyPG, PGA 1 , and PGA 2 , inhibited HIV-1 replication in acutely infected human monocyte-derived macrophages (MDM). Since PGA 1 and PGA 2 have(More)
Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export pathway that requires the Golgi-resident aspartyl protease 5 (ASP5). We demonstrate that ASP5 cleaves a highly constrained amino acid motif that has similarity to the PEXEL-motif of Plasmodium parasites. We show that ASP5 matures(More)
Reactive oxygen intermediates (ROI) play an important role in cell signaling in addition to their role in microbial killing. We have shown previously that exogenous ROI regulate activity of the enzyme 5-lipoxygenase (5-LO) in alveolar macrophages (AM). Here, we examined the role of endogenous ROI, specifically generated by NADPH oxidase, in the regulation(More)
Background. The prevalence of obesity has increased dramatically over the last decades, and its association with asthma is being increasingly recognized. Aims. Our hypothesis is that increased leptin and decreased adiponectin levels in obese subjects play a direct role in regulating inflammation in asthmatics. We wanted to examine the hypothesis that(More)
BACKGROUND With high energy fractures to the calcaneus there is the potential for significant bone loss. The loss of bone can make it difficult to fully regain calcaneal alignment. In addition these fractures are often associated with significant soft tissue injury. These two factors make it difficult to address this injury in a single stage, and can have(More)
A simple splinting method for correction of supple congenital clasped thumbs in infants. Stener lesions (interposition of the adductor pollicis aponeurosis between the two ends of the ruptured ulnar collateral ligament) have been reported to be present in Fig 3 After reduction, corrected thumb could extend and abduct well at 4 weeks postoperatively (left).(More)
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