Michael J. Bradley

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Trypanothione reductase, one of the family of flavin-dependent disulfide oxidoreductases, catalyses the reduction of trypanothione disulfide [N1, N8-bis(glutathionyl)spermidine] and related glutathionyl-polyamine disulfides. A series of subtly different, designed substrate analogues based on trypanothione were prepared by means of a solid-phase approach and(More)
Ions regulate the assembly and mechanical properties of actin filaments. Recent work using structural bioinformatics and site-specific mutagenesis favors the existence of two discrete and specific divalent cation binding sites on actin filaments, positioned in the long axis between actin subunits. Cation binding at one site drives polymerization, while the(More)
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