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How did the study come about? Although in the past century mortality in West Germany decreased similarly as in other Western nations, these changes were less pronounced in East Germany. 1,2 After German reunification in 1990, there was a lack of scientifically valid data from East Germany to explain the regional differences in life expectancy and,(More)
In automatic graph drawing a given graph has to be laid out in the plane, usually according to a number of topological and aesthetic constraints. Nice drawings for sparse nonplanar graphs can be achieved by determining a maximum planar subgraph and augmenting an embedding of this graph. This approach appears to be of limited value in practice, because the(More)
BACKGROUND Pimecrolimus cream (Elidel, SDZ ASM 981), a non-steroid inhibitor of inflammatory cytokines, is effective in the treatment of atopic dermatitis (AD). We assessed whether early treatment of AD signs/symptoms reduces the need for topical corticosteroids. OBJECTIVE To investigate the efficacy and safety of pimecrolimus cream 1% in the long-term(More)