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CaT1, the calcium transport protein 1 encoded by TRPV6, is able to generate a Ca(2+) conductance similar but not identical to the classical CRAC current in mucosal-type mast cells. Here we show that CaT1-derived Ca(2+) entry into HEK293 cells is effectively inhibited either by expression of various dominant negative N-terminal fragments of CaT1(More)
The study aimed to identify genetic lesions associated with secondary acute myeloid leukemia (sAML) in comparison with AML arising de novo (dnAML) and assess their impact on patients' overall survival (OS). High-resolution genotyping and loss of heterozygosity mapping was performed on DNA samples from 86 sAML and 117 dnAML patients, using Affymetrix(More)
The Ca(2+)-selective TRPV6 as well as the L-type Ca(2+) channel are regulated by the Ca(2+)-binding protein calmodulin (CaM). Here, we investigated the interaction of CaM with rat (r)TRPV6 in response to alterations of intracellular Ca(2+), employing Ca(2+)-imaging and patch-clamp techniques. Additionally, confocal Förster resonance energy transfer (FRET)(More)
A systematic investigation of the combination of a reference path and a reference pixel as correction method for a systematic error induced by the light source of a time-of-flight (TOF) distance measurement sensor is presented. A change of the bandwidth of the light source, e.g. caused by drifting temperature of the used LEDs results in a bandwidth(More)
Keywords: Asynchronous digital design Radiation fault-tolerance Single-event transients Single-event upsets LFSR counters Elastic pipelines Muller C-elements TCAD models Spice models SET injection experiments Ion beam radiation a b s t r a c t We present the architecture and a detailed pre-fabrication analysis of a digital measurement ASIC facilitating(More)
Fast digital timing simulations based on continuous-time, digital-value circuit models are an attractive and heavily used alternative to analog simulations. Models based on analytic delay formulas are particularly interesting here, as they also facilitate formal verification and delay bound synthesis of complex circuits. Recently, Függer et al.(More)