Michael Hickey

Learn More
BACKGROUND Physicians reverse patients' warfarin anticoagulation with frozen plasma or prothrombin complex concentrate. Our objective was to determine adverse event frequency after urgent reversal with frozen plasma versus the prothrombin complex concentrate Octaplex. METHODS AND RESULTS This natural before-after retrospective cohort study in 2 tertiary(More)
A class of graphs whose vertices represent certain combinatorial configurations and whose edges represent minimal changes is defined. A Hamilton path through such a graph indicates the existence of a minimal change algorithm for generating the configurauons. Necessary and suffioent conditions for the existence of Hamilton paths are given for this class of(More)
Nontypeable Haemophilus influenzae (NTHi) is a prevalent bacterium found in a variety of chronic respiratory diseases. The role of this bacterium in the pathogenesis of lung inflammation is not well defined. In this study we examined the effect of NTHi on two important lung inflammatory processes 1), oxidative stress and 2), protease expression.(More)
The effect of an ionospheric dynamo electric field on the electron density and total electron content (TEC) perturbations in the F layer (150–600 km altitudes) is investigated at two arbitrarily selected locations (noted as 29 • N and 60 • N in latitudes) in the presence of seismic tsunami-excited gravity waves propagating in a stratified, nondissipative(More)
This article describes the organization, curriculum, and outcomes for New Stories/New Cultures, an activity-based program for after-school enrichment in five schools in the low-income neighborhood near a major American university. The program encourages students (70% Hispanic-American, 30% African-American) to experience themselves as producers of culture,(More)
W arfarin administration has been a standard means of preventing thromboembolism in patients with atrial fibrillation, prosthetic heart valves, and venous thromboembo-lism for >50 years. 1 Because of a narrow therapeutic window, as many as 3% to 7% of patients taking warfarin are at risk of major, life-threatening bleeding, 2 and it is generally believed(More)
Pinacidil is a new and potent vasodilator, which has recently been used in the treatment of various forms of hypertension. In this study pharmacokinetic parameters were determined following administration of intravenous (0.2 mg/kg) and capsule (12.5 mg) formulations of pinacidil to twelve healthy volunteers. The serum half-life (t1/2) and volume of(More)