Michael Hehenberger

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Text literature is playing an increasingly important role in biomedical discovery. The challenge is to manage the increasing volume, complexity and specialization of knowledge expressed in this literature. Although information retrieval or text searching is useful, it is not sufficient to find specific facts and relations. Information extraction methods are(More)
Biomarkers are indicators of normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. The biopharmaceutical industry is building significant molecular-imaging capabilities and in this context is incorporating biomarker concepts throughout its research. In this paper, we discuss and propose information(More)
develops fact-based strategic insights for senior business executives around critical industry-specific and cross-industry issues. This executive brief is based on an in-depth study by the Institute's research team. It is part of an ongoing commitment by IBM Global Business Services to provide analysis and viewpoints that help companies realize business(More)
Biopharmaceutical industry is incorporating biomarker concepts throughout the R&D processes, including the inclusion of biomarker-related data in the submission of new drug applications. In this paper we discuss the role of IT and information systems that support incorporation of surrogate biomarkers in the clinical development process, with emphasis on new(More)
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