Michael Hehenberger

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Text literature is playing an increasingly important role in biomedical discovery. The challenge is to manage the increasing volume, complexity and specialization of knowledge expressed in this literature. Although information retrieval or text searching is useful, it is not sufficient to find specific facts and relations. Information extraction methods are(More)
M. Hehenberger A. Chatterjee U. Reddy J. Hernandez J. Sprengel Biomarkers are indicators of normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. The biopharmaceutical industry is building significant molecular-imaging capabilities and in this context is incorporating biomarker concepts throughout its(More)
Biopharmaceutical industry is incorporating biomarker concepts throughout the R&D processes, including the inclusion of biomarker-related data in the submission of new drug applications. In this paper we discuss the role of IT and information systems that support incorporation of surrogate biomarkers in the clinical development process, with emphasis on new(More)
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