Michael Hausser

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We aimed to estimate the number of AMPA receptors (AMPARs) bound by the quantal transmitter packet, their single-channel conductance and their density in the postsynaptic membrane at cerebellar Purkinje cell synapses. The synaptic and extrasynaptic AMPARs were examined in Purkinje cells in 2- to 4-day-old rats, when they receive synaptic inputs solely from(More)
Mammalian cerebral cortex is accepted as being critical for voluntary motor control, but what functions depend on cortex is still unclear. Here we used rapid, reversible optogenetic inhibition to test the role of cortex during a head-fixed task in which mice reach, grab, and eat a food pellet. Sudden cortical inhibition blocked initiation or froze execution(More)
Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique, care must be taken to ensure that the tool itself does not unduly affect the system under study. Here we report aberrant electrical activity, similar to interictal spikes, and accompanying fluorescence events in some genotypes of transgenic mice expressing GCaMP6(More)
Joshua T. Vogelstein, Katrin Amunts, Andreas Andreou, Dora Angelaki, Giorgio Ascoli, Cori Bargmann, Randal Burns, Corrado Cali, Frances Chance, Miyoung Chun, George Church, Hollis Cline, Todd Coleman, Stephanie de La Rochefoucauld, Winfried Denk, Ana Belen Elgoyhen, Ralph Etienne Cummings, Alan Evans, Kenneth Harris, Michael Hausser, Sean Hill, Samuel(More)
plasticity, to be a key element in associative memory formation. Circuit mechanisms of memory. By using molecular tagging techniques, we estimate that about a third of lateral amygdala neurons undergo plasticity during the formation of a memory driven by a single conditioning block. Because not all synapses on a plastic neuron undergo modification, one(More)
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