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BACKGROUND If carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the long-term effects of successful CEA. METHODS Between 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countries were(More)
Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface expression of class I molecules are inversely correlated in both chickens and humans. This relationship(More)
Mortality after coronary-artery bypass surgery (CABS) has fallen steadily over recent years. Concern remains, however, about the effect of this surgery on the brain. The problem of brain damage after CABS is multifactorial, involving microembolism, disturbed perfusion, metabolic derangement, and inflammatory responses. Microemboli numbers have been linked(More)
A longitudinal study of cognitive function after coronary artery bypass surgery examined 107 participants using 11 tests, preoperatively and at 6 days, 8 weeks, and 5 years after surgery. The overall neuropsychological (NP) change score declined at 6 days, showed some recovery at 8 weeks, and declined again at 5 years. The number of microemboli recorded(More)
PURPOSE To investigate the relationship between percentage of body fat and macular pigment (MP) optical density. METHODS One hundred healthy subjects of ages between 22 and 60 years volunteered to participate in this study. MP optical density was measured psychophysically, serum lutein and zeaxanthin were quantified by HPLC, and dietary intake of lutein(More)
BACKGROUND Neuropsychological (NP) performance after kidney transplantation (TX) has received little attention. This study compared NP functioning between dialysis and transplant patients and between living-related donor (LRD) and cadaver (CAD) transplant recipients. The association between immunosuppressive medication and NP outcomes was also examined. (More)
BACKGROUND The specific impact of transplantation on living related donor (LRD) and cadaver (CAD) kidney transplant recipients and their health-related quality of life (HQoL) has received little attention. This study examined the role of sociodemographic, medical and psychological factors in these two groups. METHODS A total of 347 transplant recipients(More)
OBJECTIVES Patients' beliefs regarding illness and treatment are important to understand responses to chronic disease. The present study aimed (i) to assess the illness representations and treatment disruption beliefs of patients with end stage renal disease (ESRD), (ii) to determine whether beliefs about illness and treatment differ between different renal(More)
PURPOSE To characterize proliferative changes in tumors during the sunitinib malate exposure/withdrawal using 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) positron emission tomography (PET)/computed tomography (CT) imaging. PATIENTS AND METHODS Patients with advanced solid malignancies and no prior anti-VEGF exposure were enrolled. All patients had metastatic(More)