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PURPOSE To analyze the results of intraocular pressure (IOP) reduction by diode laser contact cyclophotocoagulation ("cyclodiode") in cases of advanced glaucoma refractory to alternative treatments. METHODS Two hundred and ten eyes of 195 patients, ages 1 to 89 years (mean, 51 years) were followed for 3 to 30 months (mean, 10 months) after cyclodiode(More)
PURPOSE To describe the pharmacokinetics occurring after the direct injection of triamcinolone acetonide into the vitreous humor of humans. DESIGN Interventional case series. PARTICIPANTS Five patients who received a single 4-mg intravitreal injection of triamcinolone acetonide. METHODS An aqueous humor sample was obtained from 5 eyes via an anterior(More)
BACKGROUND & AIMS Drug-induced liver injury (DILI), especially from antimicrobial agents, is an important cause of serious liver disease. Amoxicillin-clavulanate (AC) is a leading cause of idiosyncratic DILI, but little is understood about genetic susceptibility to this adverse reaction. METHODS We performed a genome-wide association study using 822,927(More)
The worldwide increase in the prevalence of multi-antibiotic-resistant bacteria has threatened the physician's ability to provide appropriate therapy for infections. The relationship between antimicrobial drug concentration and infecting pathogen population reduction is of primary interest. Using data derived from mice infected with the bacterium(More)
PURPOSE To test the hypothesis that neodymium:yttrium-aluminum-garnet (Nd:YAG) laser peripheral iridotomy (LPI) significantly reduces the incidence of conversion from pigment dispersion syndrome (PDS) with ocular hypertension (OHT) to pigmentary glaucoma (PG). DESIGN Prospective, randomized, controlled 3-year trial. PARTICIPANTS One hundred sixteen eyes(More)
Trabeculectomy fails to control the intra-ocular pressure adequately in a proportion of patients. Approaches to solving this problem have involved modifications of surgery, histological studies of tissue from failed and functioning blebs, animal studies, and in vitro investigations of some of the basic processes of wound healing. This paper reviews the(More)
Two cases of pseudoexfoliation of the lens capsule are presented in which unilateral shallowing of the anterior chamber caused an acute rise in intraocular pressure. Both patients were elderly women. In one case anterior chamber shallowing was precipitated by administration of pilocarpine and the second followed central retinal vein occlusion. We suggest(More)
SUMMARY Barrett's oesophagus (BO) and gastro-oesophageal reflux disease (GERD) are precursors of oesophageal adenocarcinoma (OAC). There is an oesophageal biofilm, which changes in disease, but its role in aetiopathogenesis remains unclear. AIM To define the oesophageal microbiota of patients with GERD, BO and OAC compared with controls and to investigate(More)
This systematic review evaluates the many studies carried out to discover and evaluate non-invasive markers of non-alcoholic fatty liver disease (NAFLD). Many different strategies and methods have been used in this task, from the discovery of new markers by global 'shotgun' studies to hypothesis-driven approaches, to the development of algorithm tests based(More)
We developed a model of glaucoma fistulizing surgery in the rabbit. As is the case with wound healing in general, there was inflammation followed by repair. The sclerostomy and bleb closed due to bulk filling by granulation tissue and contraction by migratory fibroblasts (observed at three days) and by myofibroblasts (observed at ten and 17 days).(More)