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To assess the total medical costs and productivity losses associated with the 1993 waterborne outbreak of cryptosporidiosis in Milwaukee, Wisconsin, including the average cost per person with mild, moderate, and severe illness, we conducted a retrospective cost-of-illness analysis using data from 11 hospitals in the greater Milwaukee area and epidemiologic(More)
Genomic mapping of complex traits across species demands integrating genetics and statistics. In particular, because it is easily interpreted, the R(2) statistic is commonly used in quantitative trait locus (QTL) mapping studies to measure the proportion of phenotypic variation explained by molecular markers. Mixed models with random polygenic effects have(More)
OBJECTIVE To determine the incidence of all nosocomial infections (NIs) in pediatric hematology-oncology patients, as well as central venous access device (CVAD)-associated infections acquired during home care. DESIGN Prospective surveillance study. SETTING The Pediatric Hematology and Oncology Department at the University Hospital Bonn. PATIENTS All(More)
We undertook a prospective surveillance study in order to determine the incidence of healthcare-associated infections (HCAIs) in German nursing home residents. All people residing for more than one day in a 103-bed nursing home for the elderly in Bonn, Germany between December 1998 and November 1999 were included. Active surveillance was based on previously(More)
BACKGROUND This report describes a large international chocolate-associated Salmonella outbreak originating from Germany. METHODS We conducted epidemiologic investigations including a case-control study, and food safety investigations. Salmonella (S.) Oranienburg isolates were subtyped by the use of pulsed-field gel electrophoresis (PFGE). RESULTS From(More)
We estimated the frequency of clinically diagnosed Stevens-Johnson syndrome and toxic epidermal necrolysis associated with sulfadoxine-pyrimethamine (SP) and trimethoprim-sulfamethoxazole (CTX) in Blantyre District, Malawi. Cases were detected by passive surveillance at 22 health centers from March 2001 through September 2002. Denominators were estimated(More)
OBJECTIVE To determine the incidence of nosocomial infections (NIs) and fever of unknown origin among adult hematology-oncology patients. DESIGN Prospective surveillance study. SETTING The 18-bed hematology-oncology unit at the University Hospital Bonn, Bonn, Germany. PATIENTS All hematology-oncology patients admitted during a total of 8 months in(More)
A 38-year-old man with no history of pulmonary disease developed intermittent hives and bronchospasms shortly after returning from a hunting trip. Approximately one year later, examination of an excised subcutaneous nodule demonstrated infection with a mesocercaria (larval trematode). The morphology of the parasite was consistent with infection with a(More)
In the summer of 1994, an outbreak of cryptosporidiosis occurred among visitors to a state park in New Jersey. We enrolled 185 persons in a cohort study, 38 (20.5%) of whom had laboratory-confirmed cryptosporidiosis or gastrointestinal illness that met our clinical case definition. Having any exposure to lake water (e.g., swimming) was strongly associated(More)
UNLABELLED Stress fractures of varying severity were created using a rat model of skeletal fatigue loading. Periosteal woven bone formed in proportion to the level of bone damage, resulting in the rapid recovery of whole bone strength independent of stress fracture severity. INTRODUCTION A hard periosteal callus is a hallmark of stress fracture healing.(More)