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Electrocorticographic (ECoG) spectral patterns obtained during language tasks from 12 epilepsy patients (age: 12-44 years) were analysed in order to identify and characterize cortical language areas. ECoG from 63 subdural electrodes (500 Hz/channel) chronically implanted over frontal, parietal and temporal lobes were examined. Two language tasks were(More)
BACKGROUND Tuberous sclerosis complex is a genetic disorder leading to constitutive activation of mammalian target of rapamycin (mTOR) and growth of benign tumours in several organs. In the brain, growth of subependymal giant cell astrocytomas can cause life-threatening symptoms--eg, hydrocephalus, requiring surgery. In an open-label, phase 1/2 study, the(More)
OBJECTIVE In patients with intractable epilepsy, the use of interictal spikes as surrogate markers of the epileptogenic cortex has generated significant interest. Previous studies have suggested that the cortical generators of the interictal spikes are correlated with the epileptogenic cortex as identified from the ictal recordings. We hypothesize that(More)
BACKGROUND In the EXIST-1 trial, initiated on Aug 10, 2009, more than 35% of patients with subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex had at least 50% reduction in SEGA volume after 9·6 months of treatment with everolimus. In this Article, we report interim data (up to Jan 11, 2013) to support longer-term(More)
We have investigated 3-dimensional brain current density reconstruction (CDR) from intracranial electrocorticogram (ECoG) recordings by means of finite element method (FEM). The brain electrical sources are modeled by a current density distribution and estimated from the ECoG signals with the aid of a weighted minimum norm estimation algorithm. A series of(More)
PURPOSE Determination of the origin of extratemporal neocortical onset seizures is often challenging due to the rapid speed at which they propagate throughout the cortex. Typically, these patients are poor surgical candidates and many times experience recurrences of seizure activity following resection of the assumed seizure focus. METHODS We applied a(More)
BACKGROUND Tuberous sclerosis complex (TSC) is characterized by benign tumours in multiple organs, including the brain, kidneys, skin, lungs and heart. Our objective was to evaluate everolimus, an mTOR inhibitor, in the treatment of angiomyolipoma in patients with subependymal giant cell astrocytoma (SEGA) associated with TSC. METHODS EXamining everolimus(More)
PURPOSE To evaluate the level of evidence regarding the safety and efficacy of nonprescription therapies used for insomnia. REVIEWERS Members of the American Academy of Sleep Medicine's Clinical Practice Review Committee. METHODS A search of the World Wide Web was conducted using the terms insomnia, herbal remedies, and alternative treatments to develop(More)
PURPOSE To help practitioners avoid adverse perioperative events in patients with obstructive sleep-disordered breathing. REVIEWERS Members of the American Academy of Sleep Medicine's Clinical Practice Review Committee. METHODS A search of MEDLINE database using MeSH terms apnea, obstructive sleep apnea and anesthesia was conducted in October 2001. This(More)
OBJECTIVE To examine the outcomes following resection of subependymal giant cell astrocytoma (SEGA) among patients with SEGA-associated tuberous sclerosis complex (TSC). METHODS Using three large US national healthcare claims databases, we retrospectively examined the outcomes of SEGA surgery among TSC patients who underwent SEGA surgery between 2000 and(More)