MOTIVATION To allow a direct comparison of the genomic DNA sequences of sufficiently similar organisms, there is an urgent need for software tools that can align more than two genomic sequences. RESULTS We developed new algorithms and a software tool 'Multiple Genome Aligner' (MGA for short) that efficiently computes multiple genome alignments of large,… (More)
Inhalt 1 Einleitung
We have developed an alignment-free method that calculates phylogenetic distances using a maximum-likelihood approach for a model of sequence change on patterns that are discovered in unaligned sequences. To evaluate the phylogenetic accuracy of our method, and to conduct a comprehensive comparison of existing alignment-free methods (freely available as… (More)
About This Document This manual is not a technical description. As such it does not include formal definitions but instead refers to other documents containing them. It tries to avoid the excessive use of technical termini except in places where the author considers them necessary.