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Autoimmune Inner Ear Disease (AIED) is poorly characterized clinically, with no definitive laboratory test. All patients suspected of having AIED are given glucocorticoids during periods of acute hearing loss, however, only half initially respond, and still fewer respond over time.We hypothesized that AIED is a systemic autoimmune disease characterized by(More)
Streaming programs represent an increasingly important and widespread class of applications that holds unprecedented opportunities for high-impact compiler technology. Unlike sequential programs with obscured dependence information and complex communication patterns, a stream program is naturally written as a set of concurrent filters with regular(More)
JESP is a tool for statically examining the usage of user thrown exceptions in Java source code. Reported here are the first findings over a dataset of 31 publicly available Java codes, including the JavaSpecs. Of greatest interest to compiler writers are the findings that most Java exceptions are thrown across method boundaries, trys and catches occur in(More)
When diphtheria toxin encounters a low pH environment, the channel-forming T domain undergoes a poorly understood conformational change that allows for both its own membrane insertion and the translocation of the toxin's catalytic domain across the membrane. From the crystallographic structure of the water-soluble form of diphtheria toxin, a "double dagger"(More)
Diagnosing ADHD based primarily on symptom reports assumes that the number/frequency of symptoms is tied closely to the impairment imposed on an individual's functioning. That presumed linkage encourages diagnosis more by Diagnostic and Statistical Manual of Mental Disorders (4th ed.) style symptom lists than well-defined, psychometrically sound assessments(More)
The 4th CCCDTD convened in May 2012 in Montreal with the primary aim of updating the previous diagnostic approach to AD, taking into account the revised diagnostic criteria proposed by the International Working Group (IWG) and the recommendations made by the National Institute on Aging-Alzheimer Association workgroups.
Frequency-modulated (FM) signals are an integral acoustic component of ecologically natural sounds and are analyzed effectively in the auditory systems of humans and animals. Linearly frequency-modulated tone sweeps were used here to evaluate two questions. First, how rapid a sweep can listeners accurately perceive? Second, is there an effect of native(More)
In the presence of a low pH environment, the channel-forming T domain of diphtheria toxin undergoes a conformational change that allows for both its own insertion into planar lipid bilayers and the translocation of the toxin's catalytic domain across them. Given that the T domain contributes only three transmembrane segments, and the channel is permeable to(More)
  • Matthew Ian Frank, Jason Asanovic, David Miller, Atul Wentzlaf, Emmett Adya, Scott Witchel +40 others
  • 1996
A computer can never be too fast or too cheap. Computer systems pervade nearly every aspect of science, engineering, communications and commerce because they perform certain tasks at rates unachievable by any other kind of system built by humans. A computer sys-tem's throughput, however, is constrained by that sys-tem's ability to find concurrency. Given a(More)