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Although yohimbine (YOH) has been available for the treatment of male erectile dysfunction (ED) for longer than Viagra, there is a perception that little is known about the clinical performance of the drug. This review attempts, by comprehensive analysis of the literature, to cover the clinical, pharmacological, and therapeutic profiles of YOH, relevant to(More)
OBJECTIVES To determine the effect of PSD502 applied topically 5 min before intercourse on the Index of Premature Ejaculation (IPE) and intravaginal ejaculatory latency time (IELT) of men with lifelong premature ejaculation (PE) defined according to the International Society of Sexual Medicine (ISSM) definition; secondary objectives were to evaluate the(More)
A rapid method for the preparation of isolated nerve terminals (synaptosomes) is described. The material, prepared using a vertical rotor, is compared biochemically with material prepared by conventional techniques. The synaptosomes possess many characteristics expected of isolated nerve terminals, including noradrenaline release and transport against a(More)
OBJECTIVE To evaluate, in a phase II study, the efficacy and safety of a topical eutectic mixture for premature ejaculation (TEMPE), a metered-dose aerosol spray containing a eutectic mixture of lidocaine and prilocaine, as a treatment for PE. PATIENTS AND METHODS Men with PE (Diagnostic and Statistical Manual-IV definition) aged 18-75 years were(More)
INTRODUCTION PSD502 is a novel aerosolized, lidocaine-prilocaine, spray being developed for the treatment of lifelong premature ejaculation. The clinical profile of PSD502 is described in one of two double-blind, placebo-controlled, phase III studies. AIM To determine the effect of PSD502 on the Index of Premature Ejaculation (IPE) and intravaginal(More)
A survey of 3,160 pupils aged 14 to 16 years, attending schools in the 16 districts of the North East Thames Regional Health Authority, was conducted to examine their dental health status, attitudes and behaviour. The objective was to examine factors that might affect the assimilation of dental health education information, attitude modification and(More)
At low concentrations, 3H-naloxone apparently bound to two sites, of high (KD 0.50 nM) and low (KD 2.0 nM) affinity. Binding to the high affinity site was preferentially blocked by naloxonazine. This is consistent with the high and low affinity sites representing the mu 1 and mu 2 sites respectively. Binding of 3H-naloxone to the mu 1 and mu 2 sites was(More)
OBJECTIVE To describe the relationship between the pharmacokinetic and pharmacodynamic properties of dapoxetine, a drug specifically developed for treating premature ejaculation (PE). METHODS Data from various stages of the clinical development programme were analysed using validated methods for assessing ejaculatory latency. The clinical characteristics(More)
Erectile dysfunction (ED) is becoming an increasingly common problem and although oral therapies offer first-line treatment for many men, they are contraindicated or ineffective in substantial groups of patients. Intracavernosal injection (ICI) therapy is the most effective nonsurgical treatment for ED and offers an effective alternative to oral therapy.(More)
UNLABELLED What's known on the subject? and What does the study add? It is now accepted that both biological and psychological factors are important in the aetiology of premature ejaculation (PE). Of particular interest is the correlation between ejaculatory latency and penile sensory thresholds. Men with PE appear to have a heightened sensory response to(More)