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  • Elizabeth J Haining, Jing Yang, +7 authors Michael G Tomlinson
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2012 (First Published: 16 November 2012)
  • A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitous transmembrane metalloprotease that cleaves the extracellular regions from over 40 different transmembrane target proteins, includingContinue Reading
  • Michael G Tomlinson, Victoria L. Heath, Christoph W. Turck, Steve P. Watson, Arthur Weiss
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2004 (First Published: 31 December 2004)
  • The Tec family of protein-tyrosine kinases (PTKs), that includes Tec, Itk, Btk, Bmx, and Txk, plays an essential role in phospholipase Cgamma (PLCgamma) activation following antigen receptorContinue Reading
  • Gemma L. J. Fuller, Jennifer A. Williams, +7 authors Andrew C. Pearce
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2007 (First Published: 27 April 2007)
  • The two lectin receptors, CLEC-2 and Dectin-1, have been shown to signal through a Syk-dependent pathway, despite the presence of only a single YXXL in their cytosolic tails. In this study, we showContinue Reading
  • Peter J Noy, Jing Yang, +6 authors Michael G Tomlinson
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2015 (First Published: 14 December 2015)
  • A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed transmembrane metalloprotease that cleaves the extracellular regions from its transmembrane substrates. ADAM10 is essentialContinue Reading