BACKGROUND AND PURPOSE Multiple sclerosis (MS) patients are often emotionally disturbed. We investigated anger in these patients in relation to demographic, clinical, and mood characteristics. PATIENTS AND METHODS About 195 cognitively unimpaired MS patients (150 relapsing-remitting and 45 progressive) were evaluated with the State Trait Anger Expression… (More)
OBJECTIVE To measure white matter (WM) and gray matter (GM) atrophy and lesion load in a large population of patients with multiple sclerosis (MS) using a fully automated, operator-independent, multiparametric segmentation method. METHODS The study population consisted of 597 patients with MS and 104 control subjects. The MRI parameters were abnormal WM… (More)
The emergence of the World Wide Web has made it possible for individuals with appropriate computer and telecommunications equipment to interact as never before. An explosion of next-generation information systems are flooding the commercial market. This cyberspace convergence of data, computers, networks, and multimedia presents exciting challenges to… (More)
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This follow-up study assessed the 2-year clinical and magnetic resonance imaging (MRI) outcomes of patients with multiple sclerosis (MS) originally enrolled in an MRI study conducted at eight centres in south Italy (the South Italy Mobile MRI Project). Of the 597 MS patients recruited at baseline, 391 returned for the follow-up study. Of these, 363 provided… (More)
BACKGROUND To investigate in a large cohort of patients with multiple sclerosis (MS), lesion load and atrophy evolution, and the relationship between clinical and magnetic resonance imaging (MRI) correlates of disease progression. METHODS Two hundred and sixty-seven patients with MS were studied at baseline and two years later using the same MRI protocol.… (More)