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Infection with Mycobacterium ulcerans is characterised by tissue necrosis and immunosuppression due to mycolactone, the necessary and sufficient virulence factor for Buruli ulcer disease pathology. Many of its effects are known to involve down-regulation of specific proteins implicated in important cellular processes, such as immune responses and cell(More)
The virulence factor mycolactone is responsible for the immunosuppression and tissue necrosis that characterise Buruli ulcer, a disease caused by infection with Mycobacterium ulcerans In this study, we confirm that Sec61, the protein-conducting channel that coordinates entry of secretory proteins into the endoplasmic reticulum, is a primary target of(More)
Two distinct pathways deliver secretory proteins to the Sec61 protein translocase in the endoplasmic reticulum membrane. The canonical pathway requires the signal recognition particle (SRP) and its cognate receptor (SR), and targets ribosome-associated proteins to the Sec translocase. The SRP-independent pathway requires the Sec translocase-associated ER(More)
This workshop will explore the cultural and linguistic issues of textual display design, visual design, intelligent agents, social interfaces, learning modalities, information retrieval, language handling, distributed systems, and integration of Unicode features. The workshop will focus on how frameworks and methodologies can aid in providing modular(More)
A well-defined co-translational pathway couples the synthesis and translocation of nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), thereby minimizing the possibility of the hydrophobic signals and transmembrane domains that such proteins contain from being exposed to the cytosol. Nevertheless, a proportion of these(More)
A number of enzyme systems are important in the protection of cells from chemical-induced oxidative damage. Little is known of the relative importance of these enzymes during postnatal development and its is possible that changes in their activity during this period may alter the susceptibility to toxic agents. This study investigated the activities of(More)
which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary statement: The exotoxin mycolactone interferes with the biogenesis of the majority of transmembrane proteins and its actions highlight differences in how distinct classes of these proteins initially engage the Sec61(More)
The ever popular Structured Query Language (SQL) has continued to be the standard language to access relational databases for almost two decades. As SQL is widely used by all major relational database management systems (RDBMS), there is an ongoing effort to standardize syntax and semantics in the SQL (ISO/IEC) standards SQL-92 and SQL3[3]. The first part(More)
ii Acknowledgements First, and foremost, Dr. Dominique G. Homberger has supported, guided, and mentored me in earning this Ph.D. in biology, in becoming a professional anatomist and scientist, and in becoming a lifelong learner and teacher.Dean's Representative) have supported, advised, and critiqued my research as members of my advisory committee. The(More)
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