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Scope and Purpose—The location-allocation problem is a type of multifacility location problem in which both the location of new facilities and the allocation of existing facility requirements to the new facilities is determined. An example of a location-allocation problem involves the design of a distribution network where, in addition to determining the(More)
Genetic algorithms (GAs) are very efficient at exploring the entire search space; however, they are relatively poor at finding the precise local optimal solution in the region in which the algorithm converges. Hybrid GAs are the combination of improvement procedures, which are good at finding local optima, and GAs. There are two basic strategies for using(More)
A seven-step methodology is presented to determine a dimensionally correct optimal layout of a console panel for a single operator. This methodology integrates the steps in the layout design process and uses a mathematical optimization model from facility design to obtain the optimal panel layout. A major difference in this methodology from previous work is(More)
To analyze the operation of an arbitrary AGV system under selected vehicle routing strategies, we present a simulation model that can handle multiple system layouts, a varying number of AGVs, and a varying number of pedestrians moving around the system. We introduce a dynamic vehicle routing strategy based on hierarchical simulation that operates as(More)
We develop a simulation modeling framework for evaluating the effectiveness of breast cancer screening policies for US women of age 65+. We introduce a two-phase simulation approach to modeling the main components in the breast cancer screening process. The first phase is a natural-history model of the incidence and progression of untreated breast cancer in(More)